Research Directory
Professor Sharon Peacock
Clinical microbiology; environmental microbiology; genomics in diagnostic microbiology and public health; melioidosis; Staphylococcus aureus.
Departments and Institutes
Research themes
- Connections in Asia:
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India
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Laos
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Singapore
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Sri Lanka
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Thailand
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- Connections in North America:
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- USA
- Connections in Europe:
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- Germany
- The Netherlands
- Connections in Australasia:
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- Australia
- Bacteriology:
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Clinical microbiology; environmental microbiology; genomics in diagnostic microbiology and public health; melioidosis; Staphylococcus aureus.
Biography:
Professor Peacock is a clinical microbiologist based within the Departments of Medicine and Pathology, and works closely with the Health Protection Agency and the Wellcome Trust Sanger Institute.
She has recently returned to the UK after 7 years at the Wellcome Trust Major Overseas Programme in Thailand, where she directed a wide-ranging programme of bacterial disease research. There, she developed a major interest in melioidosis, a severe bacterial infection caused by the environmental bacterium (and biothreat organism) Burkholderia pseudomallei. She continues to support studies overseas on a range of aspects relating to this disease, with a particular emphasis on the development of strategies for prevention.
In the UK, Professor Peacock focuses on the role of sequencing technologies in diagnostic microbiology and public health. This follows a study demonstrating for the first time that whole genome sequencing of methicillin-resistant Staphylococcus aureus (MRSA) could define transmission pathways at both global and local levels (see reference list, below). A UKCRC Translational Infection Research Initiative grant of 3.2M has funded the development of a Cambridge UKCRC Consortium to develop tools that interpret genome sequence and provide user-friendly web-based platforms for use by public health organizations, diagnostic laboratories and healthcare workers. This will be developed to study global, national and regional transmission pathways of major drug-resistant bacterial pathogens.
Professor Peacock chairs the Cambridge Infectious Diseases Initiative; is co-director of the Infection and Immunity Theme, Cambridge Biomedical Research Centre; is a member of the Medical Research Council Infection and Immunity Board; and is a member of the Medical Technologies Advisory Committee, National Institute for Health and Clinical Excellence (NICE).
Professor Peacock is currently unable to accept PhD students.
Topics
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Key Publications
1. Koh GCKW, Maude RR, Schreiber MF, Limmathurotsakul D, Wiersinga WJ, Wuthiekanun V, Lee SJ, Mahavanakul W, Chaowagul W, Chierakul W, White NJ, van der Poll T, Day NPJ, Dougan G, Peacock SJ. Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis. Clin Infect Dis. 2011;52:717-25.
2. Harris SR, Feil EJ, Holden MT, Quail MA, Nickerson EK, Chantratita N, Gardete S, Tavares A, Day N, Lindsay JA, Edgeworth JD, de Lencastre H, Parkhill J, Peacock SJ, Bentley SD. Evolution of MRSA during hospital transmission and intercontinental spread. Science 2010;327:469–74.
3. Felgner PL, Kayala MA, Vigil A, Burk C, Nakajima-Sasaki R, Pablo J, Molina DM, Hirst S, Chew JSW, Wang D, Tan G, Duffield M, Yang R, Neel J, Chantratita N, Bancroft G, Lertmemongkolchai G, Davies DW, Vigil A, Baldi P, Peacock SJ, Titball RW. A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc Natl Acad Sci USA 2009;106:13499-504.
4. Nickerson EK, Wuthiekanun V, Wongsuvan G, Limmathurosakul D, Srisomang P, Mahavanakul W, Thaipadungpanit J, Shah KR, Arayawichanont A, Amornchai P, Thanwisai A, Day NP, Peacock SJ. Factors predicting and reducing mortality in patients with invasive Staphylococcus aureus disease in a developing country. PLoS ONE. 2009;4(8): e6512.
5. Sim BM, Chantratita N, Ooi WF, Nandi T, Tewhey R, Wuthiekanun V, Thaipadungpanit J, Tumapa S, Ariyaratne P, Sung WK, Sem XH, Chua HH, Ramnarayanan K, Lin CH, Liu Y, Feil EJ, Glass MB, Tan G, Peacock SJ, Tan P. Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates. Genome Biol. 2010;11:R89.
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