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Dr Laurence S. Tiley

Dr Laurence S. Tiley

Senior Lecturer in Molecular Virology

Fellow of Queens' College (Part 1A MIMS supervisor)

Biological Safety Officer (Dept. Vet Medicine)

Laurence Tiley is accepting applications for PhD students.

Laurence Tiley is available for consultancy.

Department of Veterinary Medicine
Madingley Road

Cambridge CB3 0ES
Office Phone: (01223) 339554 (Vet medicine) (01223) 330180 (Queens')

Departments and Institutes

Veterinary Medicine:

Research Interests

Virology

Influenza

Disease resistance

Transgenics

Host tropism

Collaborators

Key Publications

Lyall. J.E., Irvine R.M., Sherman A., McKinley T.J., Núñez A., Purdie A., Outtrim L., Brown I., Rolleston-Smith G., Sang H. and Tiley L.S. 2011 Suppression of avian influenza transmission in genetically modified chickens. Science. 331:223-226

Benfield C., Lyall, J., Kochs, G. and Tiley, L.S. 2008. Asparagine 631 variants of the Chicken Mx protein do not inhibit influenza replication in primary chicken embryo fibroblast cells or in vitro surrogate assays. J. Virol 82:7533-7539

Gog, J., Dos Santos, A.E., Dalton, R., Leclercq, I., Tiley, L.S., Elton,D., von Kirchbach, J., Naffakh, N., Escriou, N. and  Digard, P. 2007. Codon conservation in the influenza A virus genome defines RNA packaging signals. Nucleic Acids Research. 35:1897-907

Hunter CV, Tiley LS, Sang HM. 2005. Developments in transgenic technology: applications for medicine. Trends Mol Med. 11(6):293-298.

Lee, M.T.M., Klumpp, K., Digard, P.G. and Tiley, L.S. 2003. Activation of influenza virus RNA polymerase by the 5’ and 3’ terminal duplex of genomic RNA. Nucleic Acids Research. 31:1624-1632

Lee, M., Bishop, K., Medcalf, L., Elton, D., Digard, P. and Tiley, L. 2002. Definition of the minimal viral components required for the initiation of unprimed synthesis by influenza virus RNA polymerase. Nucleic Acids Research. 30:429-438

Tiley, L.S., Hagen, M., Matthews, J.T., and Krystal, M. 1994.  Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5’ ends of the viral RNAs. J. Virol., 68:5108-16