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Cambridge Infectious Diseases

The central resource for infectious disease researchers in Cambridge

Studying at Cambridge

 

Dr Olivier Restif

Dr Olivier Restif

Alborada Lecturer in Epidemiology

Royal Society University Research Fellow

Fellow of Robinson College

Olivier Restif is interested in taking PhD students.

Department of Veterinary Medicine
Madingley Road

Cambridge CB3 0ES

Termination details:

I use mathematical models combined with experimental and field-based studies to investigate the dynamics of infectious diseases at all scales, from cells to ecosystems. My research falls into four main subjects:
- Within-host dynamics of bacterial infections.
- Evolutionary ecology of immune defences.
- Microcosm studies of host-pathogen population dynamics.
- Model-Guided Fieldwork for Wildlife Infectious Diseases.

Departments and Institutes

Veterinary Medicine:
Research Fellow

Research Interests

I use mathematical models combined with experimental and field-based studies to investigate the dynamics of infectious diseases at all scales, from cells to ecosystems. My research falls into four main subjects:
A. Within-host dynamics of bacterial infections.
B. Evolutionary ecology of immune defences.
C. Microcosm studies of host-pathogen population dynamics.
D. Model-Guided Fieldwork for Wildlife Infectious Diseases

 

See here for more details on my research.

Keywords

  • Bayesian Methods
  • Ecology
  • Host-Pathogen Interaction
  • Simulation
  • Epidemiology

Topics

  • Zoonoses
  • C. elegans
  • Pseudomonas aeruginosa
  • Salmonella
  • Game Theory

Equipment

  • Statistical Methods
  • Mathematical modelling
  • Computational modelling

Key Publications

  • Coward et al (2014) The Effects of Vaccination and Immunity on Bacterial Infection Dynamics In Vivo. PLoS Pathogens, 10(9): e1004359, Full text 
  • Peel AJ et al (2014) The effect of seasonal birth pulses on pathogen persistence in wild mammal populations. Proc R Soc B, 281:20132962. Full text 
  • Restif O (2013) An offer you cannot refuse: down‐regulation of immunity in response to a pathogen's retaliation threat. J Evol Biol 26:2021-2030. Full text
  • Restif O et al. (2012) Model‐guided fieldwork: practical guidelines for multidisciplinary research on wildlife ecological and epidemiological dynamics. Ecology Letters 15:1083. Full text
  • Restif O & Amos W (2010) The evolution of sex-specific immune defences. Proceedings of the Royal Society B. Full text
  • Restif O (2009) Evolutionary epidemiology 20 years on: Challenges and prospects. Infection, Genetics and Evolution 9 (1): 108-23. [PubMed]
  • Grant AJ, Restif O, McKinley TJ, Sheppard M, Maskell DJ, Mastroeni P (2008) Modelling within-host spatiotemporal dynamics of invasive bacterial disease. PLoS Biology 6:e74 [PubMed]
  • Restif O, Grenfell BT (2007) Vaccination and the dynamics of immune evasion. Journal of the Royal Society Interface 4:143-153 [PubMed]
  • Restif O, Grenfell BT (2006) Integrating life history and cross-immunity into the evolutionary dynamics of pathogens. Proceedings of the Royal Society of London, series B 273:409-416 [PubMed]
  • Restif O, Kaltz O (2006) Condition-dependent virulence in a horizontally and vertically transmitted bacterial parasite. Oikos 114:148-158
  • Restif O, Koella JC (2004) Concurrent evolution of resistance and tolerance to pathogens. The American Naturalist 164:E90-E102 [PubMed]
  • Restif O, Koella JC (2003) Shared control of epidemiological traits in a coevolutionary model of host-parasite interactions. The American Naturalist 161:827-836 [PubMed]