Dr Olivier Restif

Research

I use mathematical models combined with experimental and field-based studies to investigate the dynamics of infectious diseases at all scales, from cells to ecosystems. My research falls into three main areas:

1. Within-host dynamics of bacterial infections.

2. Quantitative methods for multi-drug resistance.

3. One Health approach to emerging zoonotic diseases.

See here for more details on my research.

Publications

Key publications:

Vlazaki M, Huber J and Restif O (2019) Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections. Pathogens and Disease 77:fta001.https://doi.org/10.1093/femspd/ftaa001

Glennon EE, Becker DJ, Peel AJ, Garnier R, Suu-Ire RD, Gibson L, Hayman DTS, Wood JLN, Cunningham AA, Plowright RK and Restif O (2019) What is stirring in the reservoir? Modelling mechanisms of henipavirus circulation in fruit bat hosts. Philosophical Transactions of the Royal Society B: Biological Sciences 374:20190021. http://dx.doi.org/10.1098/rstb.2019.0021

Vlazaki M, Rossi O, Price DJ, McLean C, Grant AJ, Mastroeni P, Restif O. (2020) A data-based mathematical modelling study to quantify the effects of ciprofloxacin and ampicillin on the within-host dynamics of Salmonella enterica during treatment and relapse. Journal of The Royal Society Interface 17:2020.0299. https://doi.org/10.1098/rsif.2020.0299

Glennon EE, Jephcott F, Restif O, Wood JLN (2019) Estimating undetected Ebola spillovers. PLoS Neglected Tropical Diseases 13:e0007428. https://doi.org/10.1371/journal.pntd.0007428

Price DJ, Breuzé A, Dybowski R, Mastroeni P, Restif O (2017) An efficient moments-based inference method for within-host bacterial infection dynamics. PLOS Computational Biology 13(11): e1005841. https://doi.org/10.1371/journal.pcbi.1005841

Plowright RK, Peel AJ, Streicker DG, Gilbert A , McCallum H, Wood JLN, Baker ML, Restif O (2016). Transmission or within-host dynamics driving pulses of zoonotic viruses in reservoir-host populations. PLoS Neglected Tropical Diseases 10: e0004796. doi:10.1371/journal.pntd.0004796

Peel AJ, Baker, KS, Hayman DTS, Broder CC, Cunningham AA, Fooks AR, Garnier R, Wood JLN, Restif O (2018) Support for viral persistence in bats from age-specific serology and models of maternal immunity. Scientific Reports 8, 3859, doi:10.1038/s41598-018-22236-6

Coward et al (2014) The Effects of Vaccination and Immunity on Bacterial Infection Dynamics In Vivo. PLoS Pathogens, 10(9): e1004359, Full text

Peel AJ et al (2014) The effect of seasonal birth pulses on pathogen persistence in wild mammal populations. Proc R Soc B, 281:20132962. Full text

Restif O et al. (2012) Model‐guided fieldwork: practical guidelines for multidisciplinary research on wildlife ecological and epidemiological dynamics. Ecology Letters 15:1083. Full text

Subject:

Computational modelling