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Updated: 35 min ago

Wed 24 Apr 17:00: Title - TBC

5 hours 58 sec ago
Title - TBC

This Cambridge Immunology and Medicine Seminar will take place on Wednesday 24th April 2024, starting at 5:00 pm.

Speaker: Prof John Wherry; Chair, Department of Systems Pharmacology & Translational Therapeutics Richard and Barbara Schiffrin President’s Distinguished Professor Director, Institute for Immunology Co-Program Leader, Immunobiology Program, Abramson Cancer Center Co-Director, Parker Institute for Cancer Immunotherapy. University of Pennsylvania

Title: TBC

Host: Professor Menna Clatworthy, Director of CITIID , NIHR Research Professor and Professor of Translational Immunology, University of Cambridge

Refreshments will be available following the Seminar.

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Fri 14 Mar 17:30: Title to be confirmed

9 hours 14 min ago
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Abstract not available

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Fri 07 Mar 17:30: Title to be confirmed

9 hours 15 min ago
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Fri 28 Feb 17:30: Title to be confirmed

9 hours 16 min ago
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Fri 21 Feb 17:30: Title to be confirmed

9 hours 18 min ago
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Fri 14 Feb 17:30: Title to be confirmed

9 hours 19 min ago
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Fri 31 Jan 17:30: Title to be confirmed

9 hours 19 min ago
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Fri 07 Feb 17:30: Title to be confirmed

9 hours 20 min ago
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Fri 24 Jan 17:30: Title to be confirmed

9 hours 23 min ago
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Wed 05 Jun 16:00: Title to be confirmed

Wed, 27/03/2024 - 13:40
Title to be confirmed

Chaired by Cassia Hare

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Tue 23 Jul 16:00: Active Surveillance of Neglected Tropical Diseases: A Fresh Push to Identify Reservoir Hosts

Fri, 22/03/2024 - 15:08
Active Surveillance of Neglected Tropical Diseases: A Fresh Push to Identify Reservoir Hosts

Abstract: The recent wave of pandemic/epidemics in the world has necessitated that Africa join the global push to not only to be ready for future pandemics but to also preempt them. Africa is plagued with a lot of neglected tropical diseases, many of them caused by neurotropic viruses. With minimal funding of these diseases, the burden they create on quality of life and productivity of animals has not been well estimated. More important is the need for active surveillance of possible reservoir hosts for some of these Neglected Tropical Diseases, so as to proper understand their epidemiology. In this presentation, I will be speaking on West Nile, and Crimean Congo Heamorrhagic Fever viruses, and the roles that reservoirs may be playing for reverse zoonosis.

Short Citation: James Olukayode Olopade graduated with the DVM (Veterinary) degree in 1992 and obtained his MSc and PhD in 2003 and 2006, respectively, all from the University of Ibadan. He was promoted full Professor in 2011. James carried out postdoctoral trainings in Marine Biology Laboratory Woodshole, USA , as an International Brain Research Organisation (IBRO) Fellow at Penn State University, USA in 2008, and as a MacArthur and Alexander von Humboldt Fellow, both at the University of Wurzburg, Germany. He has served as Editor in Chief, Nigerian Veterinary Journal and Dean, Faculty of Veterinary Medicine. His current research areas are in neuroscience, comparative anatomy and surveillance biology. He has been funded by a variety of organisations including the International Society of Neurochemistry; the International Brain Research Organisation, the Alexander von Humboldt Foundation; the Tertiary Education Trust Fund, Nigeria, and the Cambridge Alborada Grant (UK) amongst others. He has over 160 research publications including 4 copyrights and is the most cited veterinarian in Africa as per brain research. James Olopade is currently the Principal Investigator of Alexander von Humboldt Research Hub for Zoonotic Arboviral Diseases (HRH-ZAD), a €750,000 Humboldt Research Hub funding for pandemic preparedness, and also the Director of the Veterinary Teaching Hospital, at the University of Ibadan in Nigeria.

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Fri 12 Apr 13:00: Transposon escape points to function in somatic cells?

Wed, 20/03/2024 - 17:59
Transposon escape points to function in somatic cells?

The next Cambridge Immunology and Medicine Seminar will take place on Friday 12th April 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Professor Geoff Faulkner, Professorial Research Fellow at Mater Research and Queensland Brain Institute (QBI), University of Queensland, Australia

Title: “Transposon escape points to function in somatic cells?”

Host: Paul Lehner, Professor of Immunology and Medicine and Wellcome Trust Principal Research Fellow at the University of Cambridge

Refreshments will be available following the Seminar.

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Wed 24 Apr 14:00: Host manipulation by the parasite _Cryptosporidium_

Tue, 19/03/2024 - 11:55
Host manipulation by the parasite _Cryptosporidium_

Infection by the parasite Cryptosporidium is a leading cause of child mortality, no vaccine is available and the current drug treatment against this diarrheal pathogen is inefficient. The disease is transmitted through food or water contaminated with oocysts, the chlorine-resistant parasite stage. The parasite infects the epithelial cells of the small intestine in which it replicates intracellularly. Invasion and intracellular development require extensive modifications of the host cell that remain largely unknown at the molecular level. We recently showed that parasite secreted proteins play an important role in this process, however, our knowledge remains limited. Modifications of the enterocytes as well as persistent inflammation will alter the physiology of the gut and have long lasting impact on the children. In collaboration with Ross Waller laboratory, we conducted a proteomic experiment, hyperLOPIT, on fractionated Cryptosporidium sporozoites to identify the content of the various secretory organelles. This list of potential Cryptosporidium virulence factors will help fill important gaps in our knowledge of the host/parasite interplay.

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Wed 15 May 12:00: How use of SSRI impacts placenta and mammary gland development

Mon, 18/03/2024 - 16:42
How use of SSRI impacts placenta and mammary gland development

Laura L. Hernandez, Professor-Lactation Physiology Department of Animal and Dairy Sciences University of Wisconsin-Madison

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Fri 22 Mar 13:00: Maximising the impact of CAR T cell therapy for acute leukaemia

Mon, 18/03/2024 - 14:04
Maximising the impact of CAR T cell therapy for acute leukaemia

This Cambridge Immunology and Medicine Seminar will take place on Friday 22 March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC):

Speaker: Dr Sara Ghorashian, Honorary Senior Clinical Lecturer, University College London and Consultant Paediatric Haematologist, Great Ormond Street Hospital

Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology, University of Cambridge.

This talk is part of the Immunology and Medicine Seminars series.

If you have a question about this talk, please contact Ruth Paton

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Wed 15 May 12:00: Title to be confirmed

Mon, 18/03/2024 - 10:04
Title to be confirmed

Laura L. Hernandez, Professor-Lactation Physiology Department of Animal and Dairy Sciences University of Wisconsin-Madison

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Wed 15 May 12:00: Title to be confirmed

Mon, 18/03/2024 - 10:03
Title to be confirmed

Laura L. Hernandez, Professor-Lactation Physiology Department of Animal and Dairy Sciences University of Wisconsin-Madison

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Tue 23 Jul 16:00: Title to be confirmed

Mon, 18/03/2024 - 09:57
Title to be confirmed

Chaired by Dr Raymond Bujdoso

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Fri 22 Mar 13:00: Maximising the impact of CAR T cell therapy for acute leukaemia

Wed, 13/03/2024 - 11:50
Maximising the impact of CAR T cell therapy for acute leukaemia

This Cambridge Immunology and Medicine Seminar will take place on Friday 22 March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC):

Speaker: Dr Sara Ghorashian, Honorary Senior Clinical Lecturer, University College London and Consultant Paediatric Haematologist, Great Ormond Street Hospital

Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology, University of Cambridge.

This talk is part of the Immunology and Medicine Seminars series.

If you have a question about this talk, please contact Ruth Paton

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Wed 20 Mar 14:00: Cutting back malaria: CRISPR-based approaches for antimalarial target discovery

Mon, 11/03/2024 - 14:10
Cutting back malaria: CRISPR-based approaches for antimalarial target discovery

The repeated emergence of antimalarial resistance underscores the importance of identifying new drug targets, as well as understanding the genetic architecture of current resistance pathways and any associated fitness costs. We have developed several genomics-based approaches that leverage CRISPR editing of the Plasmodium falciparum genome to validate causal resistance mutations and explore the essentiality and biological function of gene families as antimalarial targets. To more efficiently determine if compounds kill the parasite via known modes-of-action, we have generated a panel of barcoded parasite lines that encompass a wide spectrum of the known Plasmodium resistome, and have miniaturised a compound-screening assay to allow semi-automated liquid handling of parasite cultures. Competitive growth of drug-resistant lines also reveals the fitness cost of resistance. To overcome a bottleneck in evolution of resistance in the lab, we have also developed “mutator” parasite lines with an elevated mutation rate to increase the genetic complexity of parasite cultures. Finally, we are exploring whether non-coding mutations, specifically in lncRNAs, might also contribute to the parasite resistome. Collectively these approaches aim to accelerate the identification and validation of potential new targets, as well as understand the breadth of the parasite response to antimalarial challenge.

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