Biography
Professor of Medicine
Head of Department of Medicine
Immunology
Combines genetics, genomics, immunology and clinical medicine, integrating detailed laboratory analysis of mechanisms of immune regulation with a prospective translational medicine programme in major autoimmune and inflammatory diseases. The main focus of the group is investigation of the biology underlying clinical outcome in immune-mediated disease.
Contact via : hodmed@medschl.cam.ac.uk
Publications
Lee JC , … Smith KG; Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell 2013. DOI: 10.1016/j.cell.2013.08.034.
McKinney EF … Smith KG; T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection. Nature 2015. DOI: 10.1038/nature14468.
Lee JC … Smith KG. Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn’s disease. Nature Genetics 2017. DOI: 10.1038/ng.3755.
Lee JC … Smith KGC; A blood-based prognostic biomarker in inflammatory bowel disease. Gut 2019. DOI: 10.1101/535153.
Espeli M … Smith KGC; FcgRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human. Nature Communications 2019 In Press.
