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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Professor Andres Floto

Professor Andres Floto

Department of Medicine

The response of Macrophages and Dendritic cells to bacterial and mycobacterial infection


Biography:

Professor of Respiratory Biology

Infectious Respiratory Diseases

Andres Floto is Professor of Respiratory Biology at the University of Cambridge, a Wellcome Trust Senior Investigator, and Research Director of the Cambridge Centre for Lung Infection at Papworth Hospital, Cambridge.

His research is focused on understanding how immune cells interact with bacteria, how intracellular killing and inflammation are regulated and sometimes subverted during infection, how population-level whole genome sequencing can be used to reveal biology of bacterial infection, and how therapeutic enhancement of cell-autonomous immunity may provide novel strategies to treat multi drug resistant pathogens.

Clinically, he specialises in the treatment of patients with Cystic Fibrosis (CF), non-CF bronchiectasis, and infections with Nontuberculous Mycobacteria (NTM). He is co-chair of the British Thoracic Society NTM guidelines committee, the joint US CF Foundation-European CF Society (ECFS) NTM Guidelines Group and the ECFS working group on NTM

Research themes

Host-Pathogen Interactions:
Connections in Africa:
  • K-RITH Centre, Durban, South Africa

Keywords

  • Receptors
  • Signal Transduction
  • Immunology
  • Molecular Biology
  • Macrophages
  • Host-Pathogen Interaction
  • Antimicrobial resistance
  • Innate Immunity
  • Infection
  • Inflammation
  • Immune Evasion
  • Signalling
  • Toll-like receptors

Topics

  • Streptococcus
  • Staphylococcus aureus
  • Tuberculosis

Key Publications

Epidemiology of nontuberculous mycobacteria (NTM) amongst individuals with cystic fibrosis (CF). Viviani L, Harrison MJ, Zolin A, Haworth CS, Floto RA. J Cyst Fibros. 2016 Mar 31. PMID: 27050794

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis. Floto RA, et al.,. Thorax. 2016 Jan;71 Suppl 1:i1-i22. doi: 10.1136/thoraxjnl-2015-207360. PMID: 26666259

Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis. Parkins MD, Floto RA. J Cyst Fibros. 2015 May;14(3):293-304. doi: 10.1016/j.jcf.2015.03.012. PMID: 25881770

The growing threat of nontuberculous mycobacteria in CF. Floto RA, Haworth CS. J Cyst Fibros. 2015 Jan;14(1):1-2. doi: 10.1016/j.jcf.2014.12.002. PMID: 25487786

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. Schiebler M, […], Floto RA. EMBO Mol Med. 2014 Dec 22;7(2):127-39. doi: 10.15252/emmm.201404137. PMID: 25535254

Innate Immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Hepburn L, […], Floto RA. Science. 2014 Oct 31;346(6209):641-6. doi: 10.1126/science.1258705. PMID: 25359976

Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study. Bryant JM, […], Floto RA. Lancet. 2013 May 4;381(9877):1551-60. doi: 10.1016/S0140-6736(13)60632-7. PMID: 23541540

Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others. Stout JE, Floto RA. Am J Respir Crit Care Med. 2012 Nov 1;186(9):822-3. doi: 10.1164/rccm.201208-1500ED. PMID: 23118083