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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Professor Chris Abell

Professor Chris Abell

Department of Chemistry

Structural biologist focused on fragment based drug discovery and targeting enzymes in Mycobacterium tuberculosis.


Departments and Institutes

Chemistry:

Research Interests

  • fragment based drug discovery
  • targeting enzymes in Mycobacterium tuberculosis
  • microdroplets and microfluidics
  • enzyme mechanism and inhibition
  • structural biology

Keywords

  • Drug Discovery
  • Vaccine

Topics

  • Tuberculosis

Equipment

  • Microdroplets
  • Microfluidics

Key Publications

Payne R J, Riboldi-Tunnicliffe A, Kerbarh O, Abell A D, Lapthorn A J, Abell C (2007) Design, synthesis and structural studies on potent biaryl inhibitors of type II dehydroquinases ChemMedChem 2, 1015–1029.

Ciulli A, Williams G, Smith A G, Blundell T L, Abell (2006) Probing hot spots at protein-ligand binding sites: a reversed fragment-based approach using biophysical methods. J, Med. Chem. 49, 4992–5000.

Bulloch E M M, Jones M A, Parker E J, Osborne A P, Stimson E, Davies G M, Coggins J R, Abell C (2004)Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6S)-6-fluoroshikimate. J, Am. Chem. Soc. 126, 9912–9913.