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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge


Dr Charlotte Houldcroft

Research themes

Viral Pathogens:

Host-virus interactions (Epstein-Barr virus)

Cytomegalovirus in immune compromised hosts

Adenovirus molecular epidemiology

Ancient infectious disease


  • Host-Pathogen Interaction
  • Virology
  • Genetics


  • Cytomegalovirus
  • Cytomegalovirus Infection
  • EBV
  • Herpesvirus

Key Publications

Inferring the hominin origin of herpes simplex virus 2 from fossil, epidemiological and phylogenetic data. Underdown SJ, Kumar K & Houldcroft CJ. Accepted, Virus Evolution, 2017. doi: 10.1093/ve/vex026

Clinical and biological insights from viral genome sequencing. Houldcroft CJ, Beale M & Breuer J. Nature Reviews Microbiology, 2017. doi: 10.1038/nrmicro.2016.182

Severe Epstein–Barr virus infection in primary immunodeficiency and the normal host. Worth AJJ, Houldcroft CJ and Booth C. British Journal of Haematology, 2016. doi: 10.1111/bjh.14339

Detection of Low Frequency Multi-Drug Resistance and Novel Putative Maribavir Resistance in Immunocompromised Pediatric Patients with Cytomegalovirus. Houldcroft CJ et al. Frontiers in Microbiology, 2016. doi: 10.3389/fmicb.2016.01317

Neanderthal Genomics Suggests a Pleistocene Time Frame for the First Epidemiologic Transition. Houldcroft CJ & Underdown S. American Journal of Physical Anthropology, 2016. doi: 10.1002/ajpa.22985

Host genetics of Epstein–Barr virus infection, latency and disease. Houldcroft CJ & Kellam P. Reviews in Medical Virology, 2015. doi: 10.1002/rmv.1816

Host Genetic Variants and Gene Expression Patterns Associated with Epstein-Barr Virus Copy Number in Lymphoblastoid Cell Lines. Houldcroft CJ et al. PLoS ONE, 2014. doi: 10.1371/journal.pone.0108384

Disease-associated XMRV sequences are consistent with laboratory contamination. Hué S, Gray ER, Gall A, Katzourakis A, Tan CP, Houldcroft CJ et al. Retrovirology, 2010. doi: 10.1186/1742-4690-7-111

Other Publications

Rabid about whole lyssa genomes. E Archer, CJ Houldcroft
Nature Reviews Microbiology, 316 2014

Sequencing drug-resistant cytomegalovirus in pediatric patients: toward personalized medicine. C Houldcroft
Future Virology, doi:10.2217/fvl.15.58 2015

Tales from the crypt and coral reef: the successes and challenges of identifying new herpesviruses using metagenomics. CJ Houldcroft, J Breuer
Frontiers in Microbiology 6, 188

Migrating microbes: inferring ancient human migrations from pathogen genomes. Houldcroft CJ, Ramond JB, Rifkin R & Underdown SJ. Annals of Human Biology, 2017. doi: 10.1080/03014460.2017.1325515