Research
Virology
Influenza
Disease resistance
Transgenics
Host tropism
Publications
Lyall. J.E., Irvine R.M., Sherman A., McKinley T.J., Núñez A., Purdie A., Outtrim L., Brown I., Rolleston-Smith G., Sang H. and Tiley L.S. 2011 Suppression of avian influenza transmission in genetically modified chickens. Science. 331:223-226
Benfield C., Lyall, J., Kochs, G. and Tiley, L.S. 2008. Asparagine 631 variants of the Chicken Mx protein do not inhibit influenza replication in primary chicken embryo fibroblast cells or in vitro surrogate assays. J. Virol 82:7533-7539
Gog, J., Dos Santos, A.E., Dalton, R., Leclercq, I., Tiley, L.S., Elton,D., von Kirchbach, J., Naffakh, N., Escriou, N. and Digard, P. 2007. Codon conservation in the influenza A virus genome defines RNA packaging signals. Nucleic Acids Research. 35:1897-907
Hunter CV, Tiley LS, Sang HM. 2005. Developments in transgenic technology: applications for medicine. Trends Mol Med. 11(6):293-298.
Lee, M.T.M., Klumpp, K., Digard, P.G. and Tiley, L.S. 2003. Activation of influenza virus RNA polymerase by the 5’ and 3’ terminal duplex of genomic RNA. Nucleic Acids Research. 31:1624-1632
Lee, M., Bishop, K., Medcalf, L., Elton, D., Digard, P. and Tiley, L. 2002. Definition of the minimal viral components required for the initiation of unprimed synthesis by influenza virus RNA polymerase. Nucleic Acids Research. 30:429-438
Tiley, L.S., Hagen, M., Matthews, J.T., and Krystal, M. 1994. Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5’ ends of the viral RNAs. J. Virol., 68:5108-16
