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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Dr Stephen Graham

Dr Stephen Graham

Molecular mechanisms of membrane trafficking and viral infection

Stephen Graham is accepting applications for PhD students.

Stephen Graham is available for consultancy.


Departments and Institutes

Pathology:
Sir Henry Dale Fellow and University Lecturer

Research Interests

Viruses that seek to exploit the rich environment inside host cells face a logistical dilemma: How can they subvert host membrane trafficking to ensure progeny virions efficiently exit infected cells? I am investigating how viruses that acquire double membrane envelopes within cells are trafficked to and fuse with the plasma membrane.

Additionally, in order to establish a fruitful infection viruses must evade the immune surveillance systems of the host. I am interested in how large double-stranded DNA viruses have hijacked proteins of the mammalian innate immune system and ‘reprogrammed’ these proteins to suit the needs of the virus.

Keywords

  • Virion assembly
  • Immune Evasion
  • Molecular Biology
  • Host-Pathogen Interaction
  • Virology
  • Pathogen Evolution
  • Structural Biology

Topics

  • Poxvirus
  • Herpes simplex virus

Key Publications

  1. S.C. Graham, B. Nagar, G.G. Privé, J.E. Deane (2019) Molecular models should not be published without the corresponding atomic coordinates. Proceedings of the National Academy of Sciences of the USA, 116: 11099–11100
    doi: 10.1073/pnas.1904409116
  2. C. Gao, M.A. Pallett, T.I. Croll, G.L. Smith, S.C. Graham (2019) Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55. Journal of Biological Chemistry, 294: 6416–6429
    doi: 10.1074/jbc.RA118.006561
  3. J.M. Alves, M. Carneiro, J.Y. Cheng, A. Lemos de Matos, M.M. Rahman, L. Loog, P.F. Campos, N. Wales, A. Eriksson, A. Manica, T. Strive, S.C. Graham, S. Afonso, D.J. Bell, L. Belmont, J.P. Day, S.J. Fuller, S. Marchandeau, W.J. Palmer, G. Queney, A.K. Surridge, F.G. Vieira, G. McFadden, R. Nielsen, M.T.P. Gilbert, P.J. Esteves, N. Ferrand, F.M. Jiggins (2019) Parallel adaptation of rabbit populations to myxoma virus. Science, 363: 1319–1326
    doi: 10.1126/science.aau7285
  4. M.R. Hunter, G.G. Hesketh, T.H. Benedyk, A.C. Gingras, S.C. Graham (2018) Proteomic and biochemical comparison of the cellular interaction partners of human VPS33A and VPS33B. Journal of Molecular Biology, 430: 2153–2163
    doi: 10.1016/j.jmb.2018.05.019
  5. A. Albecka, D.J. Owen, L. Ivanova, J. Brun, R. Liman, L. Davies, M.F. Ahmed, S. Colaco, M. Hollinshead, S.C. Graham^ and C.M. Crump^ (2017) Dual function of the pUL7-pUL51 tegument protein complex in HSV-1 infection. Journal of Virology, 81: e02196-16
    doi: 10.1128/JVI.02196-16
  6. J. Muenzner, L.M. Traub, B.T. Kelly^, S.C. Graham^ (2017) Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin. Traffic, 18: 44–57
    doi: 10.1111/tra.12457

 (^Joint corresponding authors)