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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Dr Sergey Nejentsev MD, PhD

Dr Sergey Nejentsev, MD, PhD

Royal Society Research Fellow

Sergey Nejentsev is accepting applications for PhD students.


Research Interests

We are searching for genes in the human genome that carry sequence variants, which are involved in resistance to infection and predispose to infectious diseases. Discovery of such genes can open new biological pathways and suggest new targets for intervention. We use methods of human genetics, including genome-wide association studies (GWAS) and exome sequencing, in vitro models of infection and methods of molecular biology to understand underlying biological mechanisms protecting from infection.

Keywords

  • Genomics
  • Autoimmunity
  • Genetics
  • Latency
  • Host-Pathogen Interaction
  • Innate Immunity
  • Infection
  • Host
  • Sequencing
  • Immune Evasion
  • Signalling
  • Gene Expression

Topics

  • Genomics
  • Tuberculosis

Equipment

  • Cross-sectional and cohort studies
  • Confocal microscopy
  • Cell culture

Key Publications

Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff THM, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD (2008), “Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations”, Nat Genet 40:261–2

Nejentsev S, Walker N, Riches D, Egholm M, Todd JA (2009), “Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes”, Science 324 387–9:2009

Nejentsev S, Howson JMM, Walker NM, Szeszko JS, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LMM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA and The Wellcome Trust Case Control Consortium (2007), “Localisation of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A”, Nature 450:887–92