Fri 22 Mar 13:00: Maximising the impact of CAR T cell therapy for acute leukaemia
This Cambridge Immunology and Medicine Seminar will take place on Friday 22 March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC):
Speaker: Dr Sara Ghorashian, Honorary Senior Clinical Lecturer, University College London and Consultant Paediatric Haematologist, Great Ormond Street Hospital
Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology, University of Cambridge.
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom Refreshments will be available following the Seminar.
This talk is part of the Immunology and Medicine Seminars series.
If you have a question about this talk, please contact Ruth Paton
- Speaker: Sara Ghorashian, Honorary Associate Professor, University College London
- Friday 22 March 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Wed 28 Feb 14:00: The complexed relationships of African Schistosoma species
Abstract not available
- Speaker: Dr Bonnie Webster - Natural History Museum - London
- Wednesday 28 February 2024, 14:00-15:00
- Venue: Seminar Room, Tennis Court Road, Dept of Pathology..
- Series: Parasitology Seminars; organiser: Anna Protasio.
Tue 04 Jun 12:00: Title to be confirmed
Abstract not available
- Speaker: Fabrizio d'Adda di Fagagna
- Tuesday 04 June 2024, 12:00-13:00
- Venue: Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.
- Series: Department of Biochemistry - Tea Club Seminars; organiser: reception.
Tue 07 May 12:00: Title to be confirmed
Abstract not available
- Speaker: Patrycja Kozik
- Tuesday 07 May 2024, 12:00-13:00
- Venue: Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.
- Series: Department of Biochemistry - Tea Club Seminars; organiser: reception.
Tue 30 Apr 12:00: Title to be confirmed
Abstract not available
- Speaker: Ali Mohama Hakimi
- Tuesday 30 April 2024, 12:00-13:00
- Venue: Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.
- Series: Department of Biochemistry - Tea Club Seminars; organiser: reception.
Tue 23 Apr 12:00: Tumor targeting: from encoded libraries to clinical-stage therapeutics
Abstract not available
- Speaker: Dario Neri
- Tuesday 23 April 2024, 12:00-13:00
- Venue: Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.
- Series: Department of Biochemistry - Tea Club Seminars; organiser: reception.
Fri 05 Apr 15:00: A multifunctional biosynthetic machine that makes an interesting, underappreciated green polymer
Abstract not available
- Speaker: Martin Schmeing
- Friday 05 April 2024, 15:00-16:00
- Venue: Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.
- Series: Department of Biochemistry - Tea Club Seminars; organiser: reception.
Wed 21 Feb 12:00: New Strategies for how modification enzymes distinguish tRNAs (or not)
Abstract not available
- Speaker: Eva Kowalinski
- Wednesday 21 February 2024, 12:00-13:00
- Venue: Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.
- Series: Department of Biochemistry - Tea Club Seminars; organiser: reception.
Tue 13 Feb 12:00: Visualizing virus infection in situ by cryoET
Abstract not available
- Speaker: Peijun Zhang
- Tuesday 13 February 2024, 12:00-13:00
- Venue: Jean Thomas Lecture theatre, Sanger Building, Tennis Court Road.
- Series: Department of Biochemistry - Tea Club Seminars; organiser: reception.
Wed 14 Feb 14:00: Understanding Virus Evolution and Outbreaks through Phylodynamics: From Theory to Practice
Abstract: The recent increase in viral-driven outbreaks, epidemics, and pandemics highlights the necessity to understand virus evolution and disease dynamics within changing ecological contexts. Multidisciplinary research approaches informing phylodynamic and genomic epidemiology have proven essential in unravelling viral evolutionary trajectories and epidemiological dynamics across different scales. This talk aims to share insights from the field and my own research, emphasizing on how exploring convergent evolution can be a valuable tool for tracing common evolutionary pathways in RNA viruses relevant for global health. Additionally, I will showcase the potential applications of these approaches in enhancing targeted virus surveillance programs, using my work in Mexico as an illustrative example.
- Speaker: Marina Zamudio (UCL)
- Wednesday 14 February 2024, 14:00-15:00
- Venue: Zoom.
- Series: Worms and Bugs; organiser: Dr Ciara Dangerfield.
Fri 21 Jun 13:00: Genetics and Environment Induce Loss of FoxP3+ Regulatory T cell Function in Autoimmunity
This Cambridge Immunology and Medicine Seminar will take place on Friday 21 June 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)
Speaker: David A. Hafler, M.D. Edgerly Professor of Neurology and Immunobiology, Chairman, Department of Neurology, Yale School of Medicine
Host: Professor Menna R. Clatworthy, NIHR Research Professor and Professor of Translational Immunology, University of Cambridge
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:
Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09
Meeting ID: 897 4163 4903 Passcode: 539740
Refreshments will be available following the Seminar.
- Speaker: David A. Hafler, M.D. Edgerly Professor of Neurology and Immunobiology, Chairman, Department of Neurology, Yale School of Medicine
- Friday 21 June 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Fri 24 May 13:00: Title - TBC
This Cambridge Immunology and Medicine Seminar will take place on Friday 24 May 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)
Speaker: Dr Karen Mackenzie, Fellow and Honorary Consultant in Clinical Genetics, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh
Host: James Nathan, Wellcome Senior Clinical Fellow, Professor of Respiratory Medicine, University of Cambridge
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:
Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09
Meeting ID: 897 4163 4903 Passcode: 539740
Refreshments will be available following the Seminar.
- Speaker: Dr Karen Mackenzie, Fellow and Honorary Consultant in Clinical Genetics, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh
- Friday 24 May 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Fri 24 May 13:00: Title - TBC
his Cambridge Immunology and Medicine Seminar will take place on Friday 24 May 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)
Speaker: Dr Karen Mackenzie, Fellow and Honorary Consultant in Clinical Genetics, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh
Host: James Nathan, Wellcome Senior Clinical Fellow, Professor of Respiratory Medicine, University of Cambridge
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:
Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09
Meeting ID: 897 4163 4903 Passcode: 539740
Refreshments will be available following the Seminar.
- Speaker: Dr Karen Mackenzie, Fellow and Honorary Consultant in Clinical Genetics, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh
- Friday 24 May 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Fri 10 May 13:00: Title - TBC
This Cambridge Immunology and Medicine Seminar will take place on Friday 10 May 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)
Speaker: Professor Simon Davis, MRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, Oxford
Host: Clare Bryant, Professor of Innate Immunity, Department of Medicine, University of Cambridge.
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:
Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09
Meeting ID: 897 4163 4903 Passcode: 539740
Refreshments will be available following the Seminar.
- Speaker: Professor Simon Davis, MRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, Oxford
- Friday 10 May 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Wed 07 Feb 14:00: Generating Medium-Term Projections of Covid-19 for Wales.
One of the key tools used by the Welsh Government during its devolved pandemic decision-making was a stochastic, age-structured, local authority level, epidemiological model, designed to capture the key dynamics, and project the potential future spread and hospital impact under a range of formal assumptions. Some of these models are complex and often take several seconds or minutes to generate a single simulation on several indicators of interest, e.g. prevalence, deaths, hospital admissions, and intensive care burden. The typical approach to fitting the models to observed data consists of optimising model parameters to fit a weighted sum of the mean squared errors (MSE) between the model output and multiple time series data. In this work, we combined MSE and maximum absolute distance between projections and data using augmented Tchebyshev scalarisation as a measure of the error. Furthermore, to combat the computational expense of optimising up to 50 parameters of the model, we used a multi-objective Bayesian optimisation approach to simultaneously minimise the errors between six time-series projections and data. This approach yielded a good approximation of the sets of parameters that generated (near-)optimal trade-off fits between different targets, and was easily generalisable in post-processing if different weights were required for each data stream. The resultant trade-off front allowed us to interactively generate appropriate visual aids, and, most importantly, “Medium-Term Projections” (MTPs) for Wales, deemed plausible by experts. Our generated MTPs have been prepared in collaboration with the Scientific Pandemic Influenza Group on Modelling (SPI-M) and the UK Health Security Agency (UKHSA), and included in their weekly published reports. They were updated weekly, and delivered to stakeholders in Welsh Government, Public Health Wales, the NHS Wales Hospital Trusts, the Ambulance Trust, and directly impacted planning, assessment and decision-making.
- Speaker: Daniel Archambault (Newcastle University) & Alma Rahat (Swansea University)
- Wednesday 07 February 2024, 14:00-15:00
- Venue: Zoom.
- Series: Worms and Bugs; organiser: Dr Ciara Dangerfield.
Wed 07 Feb 14:00: What is still so fascinating about the trypanosome coat?
The cell surface coat of African trypanosomes has been studied for a long time. So you could assume that all the essentials are known. However, this is not the case. In my talk, I focus on the fabric from which this coat is woven (the VGSs) and their incredible dynamics. We’ve known for 20 years that the VSG coat can be recycled quickly, and we have a good idea of why. However, how the underlying biological processes can take place at such high speeds is only gradually coming to light. We’re trying to put the puzzle together step by step. In doing so, we sometimes come across surprising insights that can shed new light on basic cell biology. That’s what I’m going to tell you about. In addition, I would like to make my talk a plea for continuing research into parasitic protozoa, whose extreme adaptations can expand our reductionist perspective on cell biology.
- Speaker: Prof Markus Engstler - Universität Wüerzburg - Germany
- Wednesday 07 February 2024, 14:00-15:00
- Venue: Seminar Room, Tennis Court Road, Dept of Pathology..
- Series: Parasitology Seminars; organiser: Anna Protasio.
Wed 28 Feb 13:00: Bradford Hill Seminar - Social justice and health equity
Register to attend Please note this will be online webinar. Professor Sir Michael Marmot will present online via Teams.
Register on Teams to attend seminar online at https://events.teams.microsoft.com/event/e8489407-d5e4-4d3e-a91e-d95a97ed97e8@49a50445-bdfa-4b79-ade3-547b4f3986e9
Abstract Taking action to reduce health inequalities is a matter of social justice. In developing strategies for tackling health inequalities we need to confront the social gradient in health not just the difference between the worst off and everybody else. There is clear evidence when we look across countries that national policies make a difference and that much can be done in cities, towns and local areas. But policies and interventions must not be confined to the health care system; they need to address the conditions in which people are born, grow, live, work and age. The evidence shows that economic circumstances are important but are not the only drivers of health inequalities. Tackling the health gap will take action, based on sound evidence, across the whole of society.
About Professor Sir Michael Marmot Sir Michael Marmot MBBS , MPH, PhD, FRCP , FFPHM, FMedSci, FBA has been Professor of Epidemiology at University College London since 1985. He is the author of The Health Gap: the challenge of an unequal world (Bloomsbury: 2015), and Status Syndrome: how your place on the social gradient directly affects your health (Bloomsbury: 2004). Professor Marmot is the Advisor to the WHO Director-General, on social determinants of health, in the new WHO Division of Healthier Populations; Distinguished Visiting Professor at Chinese University of Hong Kong (2019-), and co-Director of the of the CUHK Institute of Health Equity. He is the recipient of the WHO Global Hero Award; the Harvard Lown Professorship (2014-2017); the Prince Mahidol Award for Public Health (2015), and 19 honorary doctorates.
Marmot has led research groups on health inequalities for nearly 50 years. He chaired the Commission on Equity and Health Inequalities in the Americas, set up in 2015 by the World Health Organization’s Pan-American Health Organization (PAHO/ WHO ) and chaired the Commission on Social Determinants of Health (CSDH), which was set up by the World Health Organization in 2005, and produced the report entitled: ‘Closing the Gap in a Generation’ in August 2008. At the request of the British Government, he conducted the Strategic Review of Health Inequalities in England post 2010, which published its report ‘Fair Society, Healthy Lives’ in February 2010. This was followed by the European Review of Social Determinants of Health and the Health Divide, for WHO EURO in 2014; Health Equity in England: Marmot Review 10 Years On, in 2020; Build Back Fairer: the COVID -19 Marmot Review in 2021; and the Report of the Commission on Social Determinants of Health in the Eastern Mediterranean Region, for WHO EMRO , also in 2021.
Professor Marmot also chaired the Expert Panel for the WCRF /AICR 2007 Second Expert Report on Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective; the Breast Screening Review for the NHS National Cancer Action Team, and was a member of The Lancet-University of Oslo Commission on Global Governance for Health. Early in his career, he set up and led a number of longitudinal cohort studies on the social gradient in health in the UCL Department of Epidemiology & Public Health (where he was head of department for 25 years): the Whitehall II Studies of British Civil Servants, investigating explanations for the striking inverse social gradient in morbidity and mortality; the English Longitudinal Study of Ageing (ELSA), and several international research efforts on the social determinants of health. He served as President of the British Medical Association (BMA) in 2010-2011, and as President of the World Medical Association in 2015. He is President of the British Lung Foundation. He is an Honorary Fellow of the American College of Epidemiology; a Fellow of the Academy of Medical Sciences; an Honorary Fellow of the British Academy, and an Honorary Fellow of the Faculty of Public Health of the Royal College of Physicians. He was a member of the Royal Commission on Environmental Pollution for six years and in 2000 he was knighted by Her Majesty The Queen, for services to epidemiology and the understanding of health inequalities. Professor Marmot is a Member of the National Academy of Medicine.
- Speaker: Professor Sir Michael Marmot, Institute of Health Equity and UCL Department of Epidemiology & Public Health
- Wednesday 28 February 2024, 13:00-14:00
- Venue: Webinar (via Teams).
- Series: Bradford Hill Seminars; organiser: Paul Browne.
Fri 22 Mar 13:00: Title - TBC
This Cambridge Immunology and Medicine Seminar will take place on Friday 22 March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC):
Speaker: Dr Sara Ghorashian, Honorary Senior Clinical Lecturer, University College London and Consultant Paediatric Haematologist, Great Ormond Street Hospital
Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology, University of Cambridge.
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom Refreshments will be available following the Seminar.
This talk is part of the Immunology and Medicine Seminars series.
If you have a question about this talk, please contact Ruth Paton
- Speaker: Sara Ghorashian, Honorary Associate Professor, University College London
- Friday 22 March 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.
Fri 08 Mar 13:00: Title - TBC
The next Cambridge Immunology and Medicine Seminar will take place on Friday 8th March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)
Speaker: Professor Luca Gattinoni, Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy
Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology (Department of Pathology) and Director (non-clinical) of the CRUK Cambridge Centre Training Programme, at the University of Cambridge.
For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:
Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09
Meeting ID: 897 4163 4903 Passcode: 539740
Refreshments will be available following the Seminar.
- Speaker: Luca Gattinoni, Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany
- Friday 08 March 2024, 13:00-14:00
- Venue: Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.
- Series: Immunology and Medicine Seminars; organiser: Ruth Paton.