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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge
 

Research

Transmissible cancers in dogs and Tasmanian devils

Publications

Key publications: 

1.         Kwon YM, Gori K, Park N, Potts N, Swift K, Wang J, Stammnitz MR, Cannell N, Baez-Ortega A, Comte S, Fox S, Harmsen C, Huxtable S, Jones M, Kreiss A, Lawrence C, Lazenby B, Peck S, Pye R, Woods G, Zimmermann M, Wedge DC, Pemberton D, Stratton MR, Hamede R, Murchison EP. Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils. PLoS Biol. 2020 Nov 24;18(11):e3000926. doi: 10.1371/journal.pbio.3000926. PMID: 33232318; PMCID: PMC7685465.

 

2.         Strakova A, Nicholls TJ, Baez-Ortega A, Ní Leathlobhair M, Sampson AT, Hughes K, Bolton IAG, Gori K, Wang J, Airikkala-Otter I, Allen JL, Allum KM, Arnold CL, Bansse-Issa L, Bhutia TN, Bisson JL, Blank K, Briceño C, Castillo Domracheva A, Corrigan AM, Cran HR, Crawford JT, Cutter SM, Davis E, de Castro KF, De Nardi AB, de Vos AP, Delgadillo Keenan L, Donelan EM, Espinoza Huerta AR, Faramade IA, Fazil M, Fotopoulou E, Fruean SN, Gallardo-Arrieta F, Glebova O, Gouletsou PG, Häfelin Manrique RF, Henriques JJGP, Horta RS, Ignatenko N, Kane Y, King C, Koenig D, Krupa A, Kruzeniski SJ, Lanza-Perea M, Lazyan M, Lopez Quintana AM, Losfelt T, Marino G, Martínez Castañeda S, Martínez-López MF, Masuruli BM, Meyer M, Migneco EJ, Nakanwagi B, Neal KB, Neunzig W, Nixon SJ, Ortega-Pacheco A, Pedraza Ordoñez F, Peleteiro MC, Polak K, Pye RJ, Ramirez-Ante JC, Reece JF, Rojas Gutierrez J, Sadia H, Schmeling SK, Shamanova O, Sherlock AG, Steenland-Smit AE, Svitich A, Tapia Martínez LJ, Thoya Ngoka I, Torres CG, Tudor EM, van der Wel MG, Vițălaru BA, Vural SA, Walkinton O, Wehrle-Martinez AS, Widdowson SAE, Zvarich I, Chinnery PF, Falkenberg M, Gustafsson CM, Murchison EP. Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer. Nat Commun. 2020 Jun 16;11(1):3059. doi: 10.1038/s41467-020-16765-w. PMID: 32546718; PMCID: PMC7297733.

 

3.         Baez-Ortega A, Gori K*, Strakova A*, Airikkala-Otter I, Allen JL, Allum KM, Bansse-Issa L, Bhutia TN, Bisson JL, Briceño C, Castillo Domracheva A, Corrigan AM, Hugh R. Cran HR, Crawford JT, Davis E, de Castro KF, De Nardi AB, de Vos AP, Delgadillo Keenan L, Donelan EM, Espinoza Huerta AR, Faramade IA, Fazil F, Fotopoulou E, Fruean SN, Gallardo-Arrieta F, Glebova O, Gouletsou PG, Häfelin Manrique RF, Henriques JJGP, Horta RS, Ignatenko N, Kane Y, King C, Koenig D, Krupa A, Kruzeniski SJ, Kwon YM, Lanza-Perea, Lazyan M, Lopez Quintana AM, Losfelt T, Marino G, Martínez Castañeda S, Martínez-López MF, Masuruli BM, Meyer M, Migneco EJ, Nakanwagi BN, Neal K, Neunzig W, Ní Leathlobhair M, Nixon SJ, Onsare MM, Ortega-Pacheco A, Pedraza-Ordoñez F, Peleteiro MC, Polak K, Pye RJ, Reece JF, Rojas Gutierrez J, Sadia H, Schmeling SK, Shamanova O, Sherlock AG, Stammnitz M, Steenland-Smit AE, Svitich A, Swarisch I, Tapia Martínez LJ, Thoya Ngoka IT, Torres CG, Tudor EM, van der Wel MG, Vițălaru BA, Vural SA, Walkinton W, Wang J, Wehrle-Martinez AS, Widdowson SAE, Stratton MR, Alexandrov LB, Martincorena I, Murchison EP. 2019. Somatic evolution and global expansion of an ancient transmissible cancer lineage. Science. Aug 2; 365(6452) doi: 10.1126/science.aau9923

 

 

4.         Ní Leathlobhair M, Perri AR, Irving-Pease EK, Witt KE, Linderholm A, Haile J,, Lebrasseur O, Ameen C, Blick J, Boyko AR, Brace S, Nunes Cortes Y, Crockford SJ, Dimopoulos EA, Eldridge M, Gopalakrishnan S, Gori KC, Grimes V, Guiry E, Hansen AJ, Hulme-Beaman A, Johnson J, Kitchen A, Kwon YM, Lope CP, Manin A, Martin T, Meyer M, Myers KN, Omura M, Sciulli P, Sinding MS, Strakova A, Widga C, Willerslev E, Barnes I, Gilbert MTP, Dobney KM, Malhi RS, Murchison EP*, Larson G*, Frantz LAF* 2018 The Evolutionary History of Dogs in the Americas. Science. Jul 6;361(6397):81-85. doi: 10.1126/science.aao4776

 

5.         Kwon YM, Stammnitz MR, Wang J, Swift K, Knowles GW, Pye RJ, Kreiss A, Peck S, Fox S, Pemberton D, Jones ME, Hamede R, Murchison EP 2018 Tasman-PCR: A genetic diagnostic assay for Tasmanian devil facial tumour diseases. Royal Soc Open Sci. Oct 3, doi:10.1098/rsos.180870 (10 pages)

6.         Stammnitz MR, Coorens THH, Gori KC, Hayes D, Fu B, Wang J, Martin-Herranz DE, Alexandrov LB, Baez-Ortega A, Barthorpe S, Beck A, Giordano F, Knowles GW, Kwon YM, Hall G, Price S, Pye RJ, Tubio JMC, V.T. Siddle HVT, Sohal, SS, Woods GM, McDermott U, Yang F, Garnett MJ, Ning Z, Murchison EP 2018 The origins and vulnerabilities of two transmissible cancers in Tasmanian devils. Cancer Cell. 33:607-619. doi: 10.1016/j.ccell.2018.03.013

Professor of comparative oncology and genetics
Professor Elizabeth  Murchison
Takes PhD students
Not available for consultancy

Affiliations

Classifications: 
Departments and institutes: 
Person keywords: 
Genomics
Genetics
Molecular Biology
Host-Pathogen Interaction
Veterinary Science
Pathogen Evolution
Pathogenesis
Immune Evasion
Macrophages
Infection
T-Cell
Bioinformatics
Immunopathogenesis
Gene Expression
Gene Regulation
Evolution
Immunology
MHC
Cross-species transmission
Innate Immunity
Transcriptomics
Dendritic Cells