Dr Weidong Jing

I study the role of innate immunity, particularly the inflammasome and pyroptosis pathways, in host defence against infection and inflammatory diseases.

I investigate the structure-function relationships of the NLRC4 inflammasome and its dysregulation in inflammatory bowel disease and autoinflammation, using CRISPR-based gene editing and advanced imaging approaches, including cryo-electron tomography and single-molecule fluorescence spectroscopy. My research also examines how bacterial lipoproteins drive host inflammatory responses and cell death. I aim to identify mechanisms of inflammasome regulation with therapeutic potential.