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Mon 05 Sep 14:00: Of novel MAMPs and DAMPs: Discovery of novel inflammatory pathways mediated by innate immunity Prof Alex Weber, University of Tübingen, Germany. Hosted by Prof Felix Randow

Mon, 05/09/2022 - 10:07
Of novel MAMPs and DAMPs: Discovery of novel inflammatory pathways mediated by innate immunity

Innate Immunity employs so-called pattern recognition receptors (PRRs) for initiating inflammation as a step towards resolving both infectious and sterile insults. These pathways are triggered by microbe-associated (MAMPs) or danger-associated (DAMPs) molecular patterns, respectively. We recently discovered two novel MAMP and DAMP pathways. Firstly, we found the secreted host enzyme, CHIT1 , to convert the inert polymeric MAMP and fungal cell wall/allergen component, chitin, into diffusible chitin oligomers that can be sensed by TLR1 -TLR2 co-receptor/receptor heterodimers, a process promoted by lipopolysaccharide binding protein (LBP) and CD14 . Our study shows the existence of an inducible system of MAMP generation within the human host that enables contact-independent immune activation by diffusible MAMP ligands with striking similarity to the plant kingdom. Secondly, we identified naRNA (NET-associated RNA ), as a new canonical component of neutrophil extracellular traps (NETs) and a potent disease-exacerbating novel DAMP . naRNA, in complex with the host antimicrobial peptide LL37 , propagated a self-amplifying cycle of NET formation in naïve neutrophils, dependent on TLR8 in humans and Tlr13 in mice, in vitro and in vivo. Our data not only highlight naRNA as a novel DAMP driving immune activation; naRNA also provides a molecular link between the reported respective pathophysiological roles of NETs and extracellular RNA in multiple diseases, and suggest blockade of TLR -mediated RNA sensing as a potential new interventional target.

Prof Alex Weber, University of Tübingen, Germany. Hosted by Prof Felix Randow

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Fri 07 Oct 16:00: Cell death and decision making in macrophages during inflammation Associate Professor Jelena Bezbradica Mirkovic, Kennedy Institute, Oxford. Hosted by Professor Felix Randow

Mon, 05/09/2022 - 10:07
Cell death and decision making in macrophages during inflammation

Abstract not available

Associate Professor Jelena Bezbradica Mirkovic, Kennedy Institute, Oxford. Hosted by Professor Felix Randow

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Wed 14 Sep 13:30: Deciphering gene expression regulation in health and disease using integrative omics approaches This talk will take place online via Zoom & Kings Hedges Room

Mon, 15/08/2022 - 14:53
Deciphering gene expression regulation in health and disease using integrative omics approaches

The development of an adult human being from a single fertilized egg is accompanied by the generation of ~200 functionally distinct cell types. Each of these cell types expresses only a subset of the 20.000 genes that the human genome encodes for. Cell-type specific gene expression patterns thus ensure the generation of hundreds of phenotypes based on a single genotype. Transcription factors play an important role in driving cell-type specific gene expression, but so-called epigenetic modifications of DNA and core histones also regulate changes in gene expression and phenotype during development and during adult life. Our lab is integrating state-of-the-art quantitative mass-spectrometry based (interaction) proteomics and next generation DNA sequencing technology to decipher (epi)genetic regulation of gene expression in (differentiated) stem cells. In my lecture I will provide an overview of some of our recent results related to these topics.

Michiel Vermeulen performed his doctoral work in the laboratory of Henk Stunnenberg at the University of Nijmegen in the Netherlands. In 2005 he joined the lab of Matthias Mann in Munich, Germany as a post-doctoral fellow. In 2009 he was appointed as assistant professor and in 2013 as associate professor at the University Medical Center Utrecht in The Netherlands. In February 2014 he was appointed as full professor at the Radboud University in Nijmegen, The Netherlands. He is the current research director of the RIMLS -Science institute at the Radboud University. He is also one of the founding members of the Oncode Institute. In 2022 he was elected as member of EMBO .

Click here to join live – https://us06web.zoom.us/j/81723173978

This talk will take place online via Zoom & Kings Hedges Room

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Wed 30 Nov 16:00: Defining genetic and environmental determinants of malaria transmission This is a hybrid talk. You can attend in person or via zoom. See abstract for details

Mon, 08/08/2022 - 15:31
Defining genetic and environmental determinants of malaria transmission

This talk will be broadcasted via Zoom. Please use this link to gain access.

This is a hybrid talk. You can attend in person or via zoom. See abstract for details

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Mon 17 Oct 19:30: CSAR lecture - Antimicrobial resistance (TBC)

Fri, 01/07/2022 - 19:54
CSAR lecture - Antimicrobial resistance (TBC)

Abstract not available

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