Veterinary Medicine

What I do:

I am developing methods to better understand accessory genome evolution. By analysing non-SNP variation, namely the gain and loss of whole genes and mobile elements, within a phylogenetic framework, my work aims to characterise evolutionary rates in the accessory genome and to examine how gene gain/loss and selection give rise to the variation observed in bacterial accessory genomes over different timescales.

What I do:

I am currently working as a Research Assistant for Dr Caroline Trotter to investigate the epidemiology of pneumococcal disease in Africa. We are currently working to review existing pneumococcal data sets from the African meningitis belt and use this data to analyses prevention and control strategies of pneumococcal disease/outbreaks with a focus on displaced populations.

What I do:

Currently, I'm investigating the role of uncultured bacteria in the human gut, with the goal of understanding how the composition of the gut microbiome may influence the incidence of gut-related human diseases.

What I do:

I study meta-genomics analysis of the human gut microbiome and the development of potential antibacterial agents derived from gut microbes.

What I do:

Applying machine learning for the discovery of novel antimicrobial resistance variants in Klebsiella pneumoniae.

Research Interests:

• Antimicrobial resistance
• Bacterial genomics
• Machine learning
• Single-cell sequencing

Research focus:

• Epidemiology and mathematical modelling to support the infant immunisation schedule in England and Wales.
• Estimating the number of cases prevented by introducing a MenACWY vaccination dose into the UK infant schedule. - Funded by the HPRU for immunisation and presented to the JCVI.

What I do:

I am a research-active veterinary pathologist focussing on mammary gland biology and pathology. As such I am interested in mastitis and the mammary gland's response to mastitis pathogens. A secondary interest lies in the field of lagomorph pathology including host response to hepatic parasites.

I am interested in using mathematical models to inform decisions on vaccination policies on meningitis in the African meningitis belt. Currently, my work focuses on figuring the key age group(s) to be targeted on the pentavalent vaccines due to be licenced by the end of 2022 in the African meningitis belt in order to maximize health benefits at a minimum cost.