Advances in the Release of Amide-Containing Molecules
Chemistry. 2025 Jan 21:e202404413. doi: 10.1002/chem.202404413. Online ahead of print.
ABSTRACT
The ability to release a molecule from a larger construct in a controlled manner is of great importance to produce effective prodrugs, antibody-drug conjugates, and chemical probes. Amides are ubiquitous functional groups and yet methods to utilise them as molecular release handles are seldom reported. This concept article highlights the advances made in amide release strategies and how these approaches have been utilised.
PMID:39836098 | DOI:10.1002/chem.202404413
A framework towards implementation of sequencing for antimicrobial-resistant and other health-care-associated pathogens
Lancet Infect Dis. 2025 Jan 17:S1473-3099(24)00729-1. doi: 10.1016/S1473-3099(24)00729-1. Online ahead of print.
ABSTRACT
Antimicrobial resistance continues to be a growing threat globally, specifically in health-care settings in which antimicrobial-resistant pathogens cause a substantial proportion of health-care-associated infections (HAIs). Next-generation sequencing (NGS) and the analysis of the data produced therein (ie, bioinformatics) represent an opportunity to enhance our capacity to address these threats. The 3rd Geneva Infection Prevention and Control Think Tank brought together experts to identify gaps, propose solutions, and set priorities for the use of NGS for HAIs and antimicrobial-resistant pathogens. The major deliverable recommendation from this meeting was a proposed framework for implementing the sequencing of HAI pathogens, specifically those harbouring antimicrobial-resistance mechanisms. The key components of the proposed framework relate to wet laboratory quality, sequence data quality, database and tool selection, bioinformatic analyses, data sharing, and NGS data integration, to support public health and actions for infection prevention and control. In this Personal View we detail and discuss the framework in the context of global implementation, specifically in low-income and middle-income countries.
PMID:39832513 | DOI:10.1016/S1473-3099(24)00729-1