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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Dr Stephen Baker

Dr Stephen Baker

Department of Medicine, CITIID.

Molecular microbiologist; enteric infections in developing countries with an emphasis on Norovirus, Shigella spp. and Salmonella Typhi.


Biography:

Stephen Baker is a Professor of molecular microbiology was located at the Wellcome Africa- Asia programme in Vietnam for 11 years, where he established an internationally recognised programme of research on enteric (gastrointestinal) infections. This work has been closely linked to work at University of Cambridge and the Sanger Institute leading to >40 co-authored publications since 2013. The work in Stephen’s group will focusses on understanding how specific bacteria that cause infectious disease in humans in low-middle income countries evolve and spread with a specific focus on typhoid fever, bacillary dysentery (Shigella), as well as other diarrheal diseases such as cholera and rotavirus. The areas of research he plans to explore within CITIID over the next 5 years will include; continuing work on the phylogeography of enteric bacteria, looking more closely at evolutionary adaptation and clonal replacement of gastrointestinal pathogens in endemic settings through cohort studies and hospital surveillance. More broadly the key areas of focus will be the impact of antimicrobial access and treatment on the gut microbiota and the generation of drug resistant pathogens. His work will maintain an international focus and will lead into developing new interventions for treating and preventing infections cause by antimicrobials resistant pathogens.

 

Keywords

  • Global Health
  • Genetics
  • Asia

Topics

  • Shigella
  • Salmonella Typhi
  • Norovirus

Equipment

  • Bioinformatics

Key Publications

Park SE, Pham DT… Baker S. The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa. Nature 2018. DOI: 10.1038/s41467-018-07370-z

de Alwis R, Tu LTP … Baker S, The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study. Journal of Infectious Disease 2018; DOI: 10.1093/infdis/jiy501

Mather AE, Phuong TLT … Baker S;New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.
MBio 2018. DOI: 10.1128/mBio.01056-18

Andrews JR, Baker S…Lo NCTyphoid conjugate vaccines: a new tool in the fight against antimicrobial resistance. Lancet Infectious Disease 2018. DOI: 10.1016/S1473-3099(18)30350-5

Thi Quynh Nhi L, de Alwis R … Baker S; Quantifying antimicrobial access and usage for paediatric diarrhoeal disease in an urban community setting in Asia. Journal Antimicrobial Chemotherapy 2018. DOI: 10.1093/jac/dky231