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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Professor James Wood

Professor James Wood

Department of Veterinary Medicine

Veterinarian, epidemiology with interests in the infection dynamics and control of a number of diseases in Africa and globally.

James Wood is available for consultancy.

Madingley Road
Cambridge

Biography:

Head of Department of Veterinary Medicine 
Alborada Professor of Equine and Farm Animal Science

Infection dynamics and control of diseases.

My research interests focus on the dynamic processes represented in all infectious diseases, at scales from the cellular and sub-cellular through to the more traditionally studied epidemiological scales of the population and metapopulation. Mathematical modelling and more traditional epidemiological approaches are combined with detailed molecular studies of pathogen and host in a multidisciplinary framework.

All studies of any infection must also consider the ecology of the host as well as of the infection itself and its pathogenesis. I have particular interests in the epidemiological dynamics of various virus infections of humans and other animals, including influenza, African horse sickness, canine rabies and emergent lyssavirus and henipavirus infections and the methods needed to study them. Bovine tuberculosis poses interesting challenges at the interface of science and policy and is an important disease and challenge. Funded studies include the emergence of zoonotic viruses, especially in Africa, transmission dynamics of mammalian influenza viruses and their variants through natural hosts and rabies dynamics. I co-supervise several students working on the dynamics of emergent viral infections in bats, in particular Eidolon helvum, in Ghana. In addition to my research interests, I am also involved in the Cambridge-Africa programme, which focuses on building links between Cambridge and African Institutions and which aims to strengthen Africa's own capacity for a sustainable research.

My position and research is generously supported by The ALBORADA Trust .

Research themes

Infectious Disease Dynamics:

Emergence and epidemiology of infectious diseases

Connections in Africa:
  • Ghana
  • Ethiopia- Ethicobots

Keywords

  • Ecology
  • Epidemiology
  • Global Health
  • Africa
  • Developing World
  • Dynamics
  • Disease vectors

Topics

  • Henipavirus
  • Rabies
  • Zoonoses
  • Tuberculosis
  • Emerging viral diseases
  • Influenza (Flu)

Key Publications

Lo Iacono, G., Cunningham, A.A., Bett, B., Grace, D., Redding, D.W. & Wood, J.L.N. (2018) Environmental limits of Rift Valley fever revealed using ecoepidemiological mechanistic models. PNAS www.pnas.org/cgi/doi/10.1073/pnas.1803264115

AJK Conlan, M Vordermeier, MCM de Jong, JLN Wood (2018) The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis eLife 7, e27694

TJ McKinley, D Lipschutz-Powell, AP Mitchell, JLN Wood, AJK Conlan (2018) Risk factors and variations in detection of new bovine tuberculosis breakdowns via slaughterhouse surveillance in Great Britain. PloS ONE 13 (6), e0198760

DTS Hayman, AD Luis, O Restif, KS Baker, AR Fooks, C Leach, (2018)  Maternal antibody and the maintenance of a lyssavirus in populations of seasonally breeding African bats. PloS ONE 13 (6), e0198563

Peel, A.J., Baker, K.S., Hayman, D.T.S., Broder, C.C., Cunningham, A.A., Fooks, A.R., Garnier, R., Wood, J.L.N. & Restif, O. (2018) Support for viral persistence in bats from age-specific serology and models of maternal immunity. Scientific Reports 8, 3859

Suu-Ire, R.D*., Begeman, L.*, Banyard, A., Breed, A.C., Drosten, C., Eggerbauer, E., Freuling, C. Gibson, L., Goharriz, H., Horton, D., Jennings, D., Kuzmin, I.V., Marston, D., Ntiamoa-Baidu, Y., Riesle, S.B., Selden, D., Wise, E., Kuiken, T., Fooks, A.R., Mueller, T., Wood, J.L.N. & Cunningham, A.A. (2018) Pathogenesis of bat rabies in a natural reservoir: comparative susceptibility of the straw-colored fruit bat (Eidolon helvum) to three strains of Lagos bat virus. PLOS Negl Trop Dis http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006311

Glennon, E.E. Restif, O., Riesle Sbarbaro, S., Garnier, G., Cunningham, A.A., Suu-Ire, R.D., Osei-Amponsah, R., Wood, J.L.N. & Peel, A.J. (2017) Domesticated animals as hosts of henipaviruses and filoviruses: A systematic review. The Veterinary Journal in press

 

Suu-Ire, R.D., Fooks, A.R.,, Banyard, A., Selden, D., Amponsah-Mensah, K., Riesle, S., Ziekah, M.Y., Ntiamoah-Baidu, Y., Wood, J.L.N. & Cunningham, A.A. (2017) Lagos Bat Virus Infection Dynamics in a Population of Free Ranging Straw-colored fruit bats (Eidolon helvum). Tropical Medicine and Infectious Diseases 2, 35

Scoones I, Jones K, Lo Iacono G, Redding DW, Wilkinson A, Wood JLN (2017) Integrative modelling for One Health: pattern, process and participation.. Phil Trans R Soc B 372 (1725) 20160164. doi: 10.1098/rstb.2016.0164

Cunningham, AA, I Scoones, JLN Wood (2017) One Health for a changing world: new perspectives from Africa. Phil. Trans. R. Soc. B 372 (1725), 20160162

Cunningham, AA, P Daszak, JLN Wood (2017) One Health, emerging infectious diseases and wildlife: two decades of progress? Phil. Trans. R. Soc. B 372 (1725), 2016016

Jephcott, FL, Wood, JLN & Cunningham, AA (2017) Facility-based surveillance for emerging infectious diseases; diagnostic practices in rural West African hospital settings: observations from Ghana. Phil. Trans. R. Soc. B 372 (1725), 20160544

Conlan, A.J.K. & Wood, J.L.N. (2016) Testing the Dairy Difference. The Veterinary Journal 217, 134-135

Lo Iacono G, Cunningham AA, Fichet-Calvet E, Garry RF, Grant DS, Leach M,  Lina M. Moses, LM, Nichols, G., Schieffelin, JS, Shaffer, JG, Webb, CT & Wood, JLN (2016) A Unified Framework for the Infection Dynamics of Zoonotic Spillover and Spread. PLOS Negl Trop Dis 10 (9), e0004957       http://dx.doi.org/10.1371/journal.pntd.0004957

Wood, J.L.N., Leach, M., Waldman, L., MacGregor, H., Fooks, A.R., Jones, K., Restif, O., Dechmann, D., Hayman, D.T.S., Baker, K.S., Peel, A.J., Kamins, A.O., Fahr, J., Ntiamoa-Baidu, Y.N., Suu-Ire, R., Breiman, R., Epstein, J. & Cunningham, A.A. (2012) A framework for the study of zoonotic disease emergence and its drivers: spillover of bat pathogens as a case study Phil Trans Roy Soc B 367 2881-2892

Park AW, Daly JM, Lewis NS, Smith DJ, Wood JLN, & Grenfell BT, (2009) Quantifying the impact of immune escape on transmission dynamics of influenza. Science 326, 726–8

Hayman DTS, Suu-Ire R, Breed AC, McEachern JA, Wang L, Wood JLN, Cunningham AA, (2008) Evidence of Henipavirus Infection in West African Fruit Bats. PLOS One 3 (7); e2739

Grenfell BT, Pybus OG, Gog JR, Wood JLN, Daly JM, Mumford JA, Holmes EC (2004), “Unifying the epidemiological and evolutionary dynamics of pathogens”, Science 303:327–332