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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Professor James Wood

Professor James Wood

Department of Veterinary Medicine.

Veterinarian, epidemiology with interests in the infection dynamics and control of a number of diseases in Africa and globally.

James Wood is available for consultancy.

Madingley Road
Cambridge

Biography:

Head of Department of Veterinary Medicine &
Alborada Professor of Equine and Farm Animal Science

I am an infectious disease epidemiologist with interests in the infection dynamics and control of a number of diseases.

Research themes

Disease Dynamics:

Emergence and epidemiology of infectious diseases

Connections in Africa:
  • Ghana
  • Ethiopia- Ethicobots

Research Interests

My interests lie in the dynamics of infections at different scales, from sub-cellular, through to within host and the population level. These dynamics studies rely on collaborations between mathematical modellers (within the vet school (Restif, Conlan, Brooks-Pollock, McKinley, Lo Iacono) and in DAMTP (Gog) and basic science researchers and are frequently multi-institutional.

My work, focussed around processes underlying emergence of infectious diseases, has various strands. Studies of mammalian influenza infection, particularly the dynamics of the generation of viral variants within hosts and during transmission (in collaboration with Murcia at Glasgow, Kellam at Sanger, Brown at VLA and Charleston at Pirbright), lyssavirus and henipavirus infections in African bat reservoir hosts and their potential impact in humans (in collaboration with Cunningham at IoZ, Fooks at AHVLA, Leach at the STEPS Centre (IDS) and many international collaborators including Webb (Colorado State University) and Ntiamoa-Baidu and Suu-Ire (University of Ghana)) and bovine Tuberculosis persistence and control (in collaboration with AHVLA).

My position and research are generously supported by The ALBORADA Trust

Keywords

  • Ecology
  • Epidemiology
  • Global Health
  • Africa
  • Developing World
  • Dynamics
  • Disease vectors

Topics

  • Henipavirus
  • Rabies
  • Zoonoses
  • Tuberculosis
  • Emerging viral diseases
  • Influenza (Flu)

Key Publications

Lo Iacono, G., Cunningham, A.A., Bett, B., Grace, D., Redding, D.W. & Wood, J.L.N. (2018) Environmental limits of Rift Valley fever revealed using ecoepidemiological mechanistic models. PNAS www.pnas.org/cgi/doi/10.1073/pnas.1803264115

AJK Conlan, M Vordermeier, MCM de Jong, JLN Wood (2018) The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis eLife 7, e27694

TJ McKinley, D Lipschutz-Powell, AP Mitchell, JLN Wood, AJK Conlan (2018) Risk factors and variations in detection of new bovine tuberculosis breakdowns via slaughterhouse surveillance in Great Britain. PloS ONE 13 (6), e0198760

DTS Hayman, AD Luis, O Restif, KS Baker, AR Fooks, C Leach, (2018)  Maternal antibody and the maintenance of a lyssavirus in populations of seasonally breeding African bats. PloS ONE 13 (6), e0198563

Peel, A.J., Baker, K.S., Hayman, D.T.S., Broder, C.C., Cunningham, A.A., Fooks, A.R., Garnier, R., Wood, J.L.N. & Restif, O. (2018) Support for viral persistence in bats from age-specific serology and models of maternal immunity. Scientific Reports 8, 3859

Suu-Ire, R.D*., Begeman, L.*, Banyard, A., Breed, A.C., Drosten, C., Eggerbauer, E., Freuling, C. Gibson, L., Goharriz, H., Horton, D., Jennings, D., Kuzmin, I.V., Marston, D., Ntiamoa-Baidu, Y., Riesle, S.B., Selden, D., Wise, E., Kuiken, T., Fooks, A.R., Mueller, T., Wood, J.L.N. & Cunningham, A.A. (2018) Pathogenesis of bat rabies in a natural reservoir: comparative susceptibility of the straw-colored fruit bat (Eidolon helvum) to three strains of Lagos bat virus. PLOS Negl Trop Dis http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006311

Glennon, E.E. Restif, O., Riesle Sbarbaro, S., Garnier, G., Cunningham, A.A., Suu-Ire, R.D., Osei-Amponsah, R., Wood, J.L.N. & Peel, A.J. (2017) Domesticated animals as hosts of henipaviruses and filoviruses: A systematic review. The Veterinary Journal in press

 

Suu-Ire, R.D., Fooks, A.R.,, Banyard, A., Selden, D., Amponsah-Mensah, K., Riesle, S., Ziekah, M.Y., Ntiamoah-Baidu, Y., Wood, J.L.N. & Cunningham, A.A. (2017) Lagos Bat Virus Infection Dynamics in a Population of Free Ranging Straw-colored fruit bats (Eidolon helvum). Tropical Medicine and Infectious Diseases 2, 35

Scoones I, Jones K, Lo Iacono G, Redding DW, Wilkinson A, Wood JLN (2017) Integrative modelling for One Health: pattern, process and participation.. Phil Trans R Soc B 372 (1725) 20160164. doi: 10.1098/rstb.2016.0164

Cunningham, AA, I Scoones, JLN Wood (2017) One Health for a changing world: new perspectives from Africa. Phil. Trans. R. Soc. B 372 (1725), 20160162

Cunningham, AA, P Daszak, JLN Wood (2017) One Health, emerging infectious diseases and wildlife: two decades of progress? Phil. Trans. R. Soc. B 372 (1725), 2016016

Jephcott, FL, Wood, JLN & Cunningham, AA (2017) Facility-based surveillance for emerging infectious diseases; diagnostic practices in rural West African hospital settings: observations from Ghana. Phil. Trans. R. Soc. B 372 (1725), 20160544

Conlan, A.J.K. & Wood, J.L.N. (2016) Testing the Dairy Difference. The Veterinary Journal 217, 134-135

Lo Iacono G, Cunningham AA, Fichet-Calvet E, Garry RF, Grant DS, Leach M,  Lina M. Moses, LM, Nichols, G., Schieffelin, JS, Shaffer, JG, Webb, CT & Wood, JLN (2016) A Unified Framework for the Infection Dynamics of Zoonotic Spillover and Spread. PLOS Negl Trop Dis 10 (9), e0004957       http://dx.doi.org/10.1371/journal.pntd.0004957

Wood, J.L.N., Leach, M., Waldman, L., MacGregor, H., Fooks, A.R., Jones, K., Restif, O., Dechmann, D., Hayman, D.T.S., Baker, K.S., Peel, A.J., Kamins, A.O., Fahr, J., Ntiamoa-Baidu, Y.N., Suu-Ire, R., Breiman, R., Epstein, J. & Cunningham, A.A. (2012) A framework for the study of zoonotic disease emergence and its drivers: spillover of bat pathogens as a case study Phil Trans Roy Soc B 367 2881-2892

Park AW, Daly JM, Lewis NS, Smith DJ, Wood JLN, & Grenfell BT, (2009) Quantifying the impact of immune escape on transmission dynamics of influenza. Science 326, 726–8

Hayman DTS, Suu-Ire R, Breed AC, McEachern JA, Wang L, Wood JLN, Cunningham AA, (2008) Evidence of Henipavirus Infection in West African Fruit Bats. PLOS One 3 (7); e2739

Grenfell BT, Pybus OG, Gog JR, Wood JLN, Daly JM, Mumford JA, Holmes EC (2004), “Unifying the epidemiological and evolutionary dynamics of pathogens”, Science 303:327–332