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Professor Julian Parkhill FMedSci

Professor Julian Parkhill, FMedSci

Head of Pathogen Genomics, The Sanger Institute

Julian Parkhill is accepting applications for PhD students.


Research Interests

Genomic analysis of bacterial pathogens

Keywords

  • Genomics
  • Evolution
  • Genetics
  • Molecular Biology
  • Host-Pathogen Interaction
  • Pathogen Evolution
  • Infection
  • Epidemiology
  • Pathogenesis
  • Bioinformatics
  • Bacteriology

Topics

  • Genomics
  • Typhoid Fever
  • Staphylococcus aureus
  • Shigellosis
  • Burkholderia pseudomallei
  • Tuberculosis
  • Diphtheria
  • Salmonella
  • Campylobacter
  • Pertussis (Whooping Cough)

Key Publications


Evidence for several waves of global transmission in the seventh cholera pandemic.
Mutreja A, Kim DW, Thomson NR, Connor TR, Lee JH, Kariuki S, Croucher NJ, Choi SY, Harris SR, Lebens M, Niyogi SK, Kim EJ, Ramamurthy T, Chun J, Wood JL, Clemens JD, Czerkinsky C, Nair GB, Holmgren J, Parkhill J and Dougan G
Nature 2011;477;7365;462-5
PUBMED: 21866102; DOI: 10.1038/nature10392

Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
García-Álvarez L, Holden MT, Lindsay H, Webb CR, Brown DF, Curran MD, Walpole E, Brooks K, Pickard DJ, Teale C, Parkhill J, Bentley SD, Edwards GF, Girvan EK, Kearns AM, Pichon B, Hill RL, Larsen AR, Skov RL, Peacock SJ, Maskell DJ and Holmes MA
The Lancet infectious diseases 2011;11;8;595-603
PUBMED: 21641281; DOI: 10.1016/S1473-3099(11)70126-8

Salmonella bongori provides insights into the evolution of the Salmonellae.
Fookes M, Schroeder GN, Langridge GC, Blondel CJ, Mammina C, Connor TR, Seth-Smith H, Vernikos GS, Robinson KS, Sanders M, Petty NK, Kingsley RA, Bäumler AJ, Nuccio SP, Contreras I, Santiviago CA, Maskell D, Barrow P, Humphrey T, Nastasi A, Roberts M, Frankel G, Parkhill J, Dougan G and Thomson NR
PLoS pathogens 2011;7;8;e1002191
PUBMED: 21876672; PMC: 3158058; DOI: 10.1371/journal.ppat.1002191

The impact of recombination on dN/dS within recently emerged bacterial clones.
Castillo-Ramírez S, Harris SR, Holden MT, He M, Parkhill J, Bentley SD and Feil EJ
PLoS pathogens 2011;7;7;e1002129
PUBMED: 21779170; PMC: 3136474; DOI: 10.1371/journal.ppat.1002129

Enterotypes of the human gut microbiome.
Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Doré J, MetaHIT Consortium, Antolín M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Mérieux A, Melo Minardi R, M'rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD and Bork P
Nature 2011;473;7346;174-80
PUBMED: 21508958; DOI: 10.1038/nature09944

Partitioning core and satellite taxa from within cystic fibrosis lung bacterial communities.
van der Gast CJ, Walker AW, Stressmann FA, Rogers GB, Scott P, Daniels TW, Carroll MP, Parkhill J and Bruce KD
The ISME journal 2011;5;5;780-91
PUBMED: 21151003; PMC: 3105771; DOI: 10.1038/ismej.2010.175

Rapid pneumococcal evolution in response to clinical interventions.
Croucher NJ, Harris SR, Fraser C, Quail MA, Burton J, van der Linden M, McGee L, von Gottberg A, Song JH, Ko KS, Pichon B, Baker S, Parry CM, Lambertsen LM, Shahinas D, Pillai DR, Mitchell TJ, Dougan G, Tomasz A, Klugman KP, Parkhill J, Hanage WP and Bentley SD
Science (New York, N.Y.) 2011;331;6016;430-4
PUBMED: 21273480; DOI: 10.1126/science.1198545

Evolutionary dynamics of Clostridium difficile over short and long time scales.
He M, Sebaihia M, Lawley TD, Stabler RA, Dawson LF, Martin MJ, Holt KE, Seth-Smith HM, Quail MA, Rance R, Brooks K, Churcher C, Harris D, Bentley SD, Burrows C, Clark L, Corton C, Murray V, Rose G, Thurston S, van Tonder A, Walker D, Wren BW, Dougan G and Parkhill J
Proceedings of the National Academy of Sciences of the United States of America 2010;107;16;7527-32
PUBMED: 20368420; PMC: 2867753; DOI: 10.1073/pnas.0914322107

Evolution of MRSA during hospital transmission and intercontinental spread.
Harris SR, Feil EJ, Holden MT, Quail MA, Nickerson EK, Chantratita N, Gardete S, Tavares A, Day N, Lindsay JA, Edgeworth JD, de Lencastre H, Parkhill J, Peacock SJ and Bentley SD
Science (New York, N.Y.) 2010;327;5964;469-74
PUBMED: 20093474; PMC: 2821690; DOI: 10.1126/science.1182395