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An Interdisciplinary Research Centre at the University of Cambridge
 

Research

I use mathematical models combined with experimental and field-based studies to investigate the dynamics of infectious diseases at all scales, from cells to ecosystems. My research falls into three main areas:
 
1. Within-host dynamics of bacterial infections.
2. Quantitative methods for multi-drug resistance.

3. One Health approach to emerging zoonotic diseases.

 

See here for more details on my research.

Publications

Key publications: 

Vlazaki M, Huber J and Restif O (2019)  Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections. Pathogens and Disease 77:fta001.https://doi.org/10.1093/femspd/ftaa001

Glennon EE, Becker DJ, Peel AJ, Garnier R, Suu-Ire RD, Gibson L, Hayman DTS, Wood JLN, Cunningham AA, Plowright RK and Restif O (2019) What is stirring in the reservoir? Modelling mechanisms of henipavirus circulation in fruit bat hosts. Philosophical Transactions of the Royal Society B: Biological Sciences 374:20190021. http://dx.doi.org/10.1098/rstb.2019.0021

Vlazaki M, Rossi O, Price DJ, McLean C, Grant AJ, Mastroeni P, Restif O. (2020) A data-based mathematical modelling study to quantify the effects of ciprofloxacin and ampicillin on the within-host dynamics of Salmonella enterica during treatment and relapse. Journal of The Royal Society Interface 17:2020.0299. https://doi.org/10.1098/rsif.2020.0299

Glennon EE, Jephcott F, Restif O, Wood JLN (2019) Estimating undetected Ebola spillovers. PLoS Neglected Tropical Diseases 13:e0007428. https://doi.org/10.1371/journal.pntd.0007428

Price DJ, Breuzé A, Dybowski R, Mastroeni P, Restif O (2017) An efficient moments-based inference method for within-host bacterial infection dynamics. PLOS Computational Biology 13(11): e1005841. https://doi.org/10.1371/journal.pcbi.1005841

Plowright RK, Peel AJ, Streicker DG, Gilbert A , McCallum H, Wood JLN, Baker ML, Restif O (2016). Transmission or within-host dynamics driving pulses of zoonotic viruses in reservoir-host populations. PLoS Neglected Tropical Diseases 10: e0004796. doi:10.1371/journal.pntd.0004796

Peel AJ, Baker, KS, Hayman DTS, Broder CC, Cunningham AA, Fooks AR, Garnier R, Wood JLN, Restif O (2018) Support for viral persistence in bats from age-specific serology and models of maternal immunity. Scientific Reports 8, 3859, doi:10.1038/s41598-018-22236-6

Coward et al (2014) The Effects of Vaccination and Immunity on Bacterial Infection Dynamics In Vivo. PLoS Pathogens, 10(9): e1004359, Full text 

Peel AJ et al (2014) The effect of seasonal birth pulses on pathogen persistence in wild mammal populations. Proc R Soc B, 281:20132962. Full text 

Restif O et al. (2012) Model‐guided fieldwork: practical guidelines for multidisciplinary research on wildlife ecological and epidemiological dynamics. Ecology Letters 15:1083. Full text

Senior Lecturer in Epidemiology
Fellow of Robinson College
Dr Olivier  Restif

Contact Details

Department of Veterinary Medicine
Madingley Road
Cambridge
CB3 0ES
Takes PhD students
Not available for consultancy

Affiliations

Classifications: 
Departments and institutes: 
Person keywords: 
Bayesian Methods
Ecology
Host-Pathogen Interaction
Antimicrobial resistance
Africa
Simulation
Epidemiology