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Infectious Disease Talks

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Talks related to infectious diseases
URL: http://talks.cam.ac.uk/show/index/29729
Updated: 34 min 56 sec ago

Tue 09 Apr 12:00: From structure prediction to therapeutics: the rapidly evolving landscape of biomolecular modeling and simulations

Tue, 27/02/2024 - 10:20
From structure prediction to therapeutics: the rapidly evolving landscape of biomolecular modeling and simulations

Abstract not available

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Wed 28 Feb 14:00: Detecting superspreaders in wildlife reservoirs of disease

Mon, 26/02/2024 - 14:40
Detecting superspreaders in wildlife reservoirs of disease

To better understand the dynamics of infectious diseases of wildlife, it is crucial to be able to fit dynamic transmission models to observed data in a robust and efficient way, in order to estimate key epidemiological parameters and generate well calibrated predictive information. In practice, epidemiological events are at best only partially observed, and as such it is necessary to infer missing information alongside the model parameters as part of the inference routine, requiring computationally intensive inference algorithms where computational load increases non-linearly with population size and with increased dimensionality of the hidden states. With this in mind, we implement a recently proposed individual forward filtering backward sampling algorithm to fit a complex individual-based epidemic model to data from a large-scale longitudinal study of bovine tuberculosis in badgers. This data set, from Woodchester Park in south-west England, comprises >2,000 badgers across 34 social groups over a 40-year period. We deal with many complexities typical to endemic wildlife disease systems: incomplete sampling of individuals over time (through capture-mark-recapture events), the use of multiple diagnostic tests, spatial meta-population structures, and non-Markovian demographic aspects such as age-dependent mortality rates (with censoring), all alongside a hidden stochastic compartmental model of disease spread. The method produces full posterior distributions for the parameters, and predictive distributions for the hidden states over time for each individual, and fits in just a few hours on a desktop machine. We also propose a novel individual-level reproduction number which accounts for major sources of uncertainty of the disease system, and from it provide quantitative evidence for the presence of superspreader badgers in Woodchester Park. The inference framework is very flexible, and could be applied to other individual-level disease systems, and we will discuss future extensions to explore further important epidemiological questions.

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Tue 09 Apr 12:00: Title to be confirmed

Mon, 26/02/2024 - 14:34
Title to be confirmed

Abstract not available

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Fri 01 Mar 15:00: Unravelling the mechanisms of a splicing regulator

Mon, 26/02/2024 - 14:33
Unravelling the mechanisms of a splicing regulator

Abstract not available

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Wed 06 Mar 14:00: Expanding BioID: the nuclear pore complex of trypanosomes

Mon, 26/02/2024 - 09:54
Expanding BioID: the nuclear pore complex of trypanosomes

Proximity labelling by a biotin ligase combined with mass spectrometry of biotin-affinity purified proteins (BioID) has become a powerful tool to investigate protein interactions in vivo in a range of organisms, including trypanosomes. We recently discovered an interesting off-label application of BioID for protein imaging by fluorescent streptavidin. We found streptavidin imaging superior to classical antibody labelling because it (i) provides a stronger signal with no loss in resolution (ii) can image proteins in phase-separated regions that are not accessible to antibodies and (iii) provides information on localization dynamics, since “historic” interactions are preserved. We have used the method, in combination with expansion microscopy, classical BioID, neural-network based in silico predictions and reverse genetics to reinvestigate the trypanosome nuclear pore complex.

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Fri 12 Apr 13:00: Transposon escape points to function in somatic cells?

Wed, 21/02/2024 - 15:57
Transposon escape points to function in somatic cells?

The next Cambridge Immunology and Medicine Seminar will take place on Friday 12th April 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Professor Geoff Faulkner, Professorial Research Fellow at Mater Research and Queensland Brain Institute (QBI), University of Queensland, Australia

Title: “Transposon escape points to function in somatic cells?”

Host: Paul Lehner, Professor of Immunology and Medicine and Wellcome Trust Principal Research Fellow at the University of Cambridge

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

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Fri 08 Mar 13:00: Empowering T Cell Therapy through Stemness and Mitochondria

Wed, 21/02/2024 - 15:56
Empowering T Cell Therapy through Stemness and Mitochondria

The next Cambridge Immunology and Medicine Seminar will take place on Friday 8th March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Professor Luca Gattinoni, Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy

Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology (Department of Pathology) and Director (non-clinical) of the CRUK Cambridge Centre Training Programme, at the University of Cambridge.

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

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Fri 21 Jun 13:00: Genetics and Environment Induce Loss of FoxP3+ Regulatory T cell Function in Autoimmunity

Wed, 21/02/2024 - 15:32
Genetics and Environment Induce Loss of FoxP3+ Regulatory T cell Function in Autoimmunity

This Cambridge Immunology and Medicine Seminar will take place on Friday 21 June 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: David A. Hafler, M.D. Edgerly Professor of Neurology and Immunobiology, Chairman, Department of Neurology, Yale School of Medicine

Host: Professor Menna R. Clatworthy, NIHR Research Professor and Professor of Translational Immunology, University of Cambridge

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

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Fri 10 May 13:00: Title - TBC

Wed, 21/02/2024 - 14:19
Title - TBC

This Cambridge Immunology and Medicine Seminar will take place on Friday 10 May 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Professor Simon Davis, MRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, Oxford

Host: Clare Bryant, Professor of Innate Immunity, Department of Medicine, University of Cambridge.

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

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Fri 12 Apr 13:00: "Transposon escape points to function in somatic cells?"

Wed, 21/02/2024 - 14:11
"Transposon escape points to function in somatic cells?"

The next Cambridge Immunology and Medicine Seminar will take place on Friday 12th April 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Professor Geoff Faulkner, Professorial Research Fellow at Mater Research and Queensland Brain Institute (QBI), University of Queensland, Australia

Title: “Transposon escape points to function in somatic cells?”

Host: Paul Lehner, Professor of Immunology and Medicine and Wellcome Trust Principal Research Fellow at the University of Cambridge

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

Add to your calendar or Include in your list

Fri 12 Jul 13:00: TBC

Wed, 21/02/2024 - 14:06
TBC

This Cambridge Immunology and Medicine Seminar will take place on Friday 12 July 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Sophie Acton, LMCB Group Leader, Senior Cancer Research UK Fellow, MRC -UCL, University College London

Host: Tim Halim, PhD, Sir Henry Dale Fellow, Cancer Research UK – Cambridge Institute, University of Cambridge

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

Add to your calendar or Include in your list

Fri 12 Jul 13:00: TBC

Wed, 21/02/2024 - 12:51
TBC

This Cambridge Immunology and Medicine Seminar will take place on Friday 12 July 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Sophie Acton, LMCB Group Leader, Cancer Research UK Senior Research Fellow, MRC -UCL

Host: Tim Halim, PhD, Sir Henry Dale Fellow, Cancer Research UK – Cambridge Institute, University of Cambridge

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

Add to your calendar or Include in your list

Fri 12 Apr 13:00: "Transposon escape points to function in somatic cells?"

Wed, 21/02/2024 - 11:23
"Transposon escape points to function in somatic cells?"

The next Cambridge Immunology and Medicine Seminar will take place on Friday 12th April 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Professor Geoff Faulkner, Professorial Research Fellow at Mater Research and Queensland Brain Institute (QBI), University of Queensland, Australia

Title: “Transposon escape points to function in somatic cells?”

Host: Paul Lehner, Professor of Immunology and Medicine and Wellcome Trust Principal Research Fellow at the University of Cambridge

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

Add to your calendar or Include in your list

Fri 08 Mar 13:00: "Empowering T Cell Therapy through Stemness and Mitochondria."

Tue, 20/02/2024 - 23:51
"Empowering T Cell Therapy through Stemness and Mitochondria."

The next Cambridge Immunology and Medicine Seminar will take place on Friday 8th March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Professor Luca Gattinoni, Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy

Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology (Department of Pathology) and Director (non-clinical) of the CRUK Cambridge Centre Training Programme, at the University of Cambridge.

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom:

Join Zoom Meeting: https://cam-ac-uk.zoom.us/j/89741634903?pwd=dzcxbU45NjAwQXo1dmlNMjR3V0lUUT09

Meeting ID: 897 4163 4903 Passcode: 539740

Refreshments will be available following the Seminar.

Add to your calendar or Include in your list

Fri 22 Mar 13:00: Maximising the impact of CAR T cell therapy for acute leukaemia

Mon, 19/02/2024 - 15:24
Maximising the impact of CAR T cell therapy for acute leukaemia

This Cambridge Immunology and Medicine Seminar will take place on Friday 22 March 2024, starting at 1:00 pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC):

Speaker: Dr Sara Ghorashian, Honorary Senior Clinical Lecturer, University College London and Consultant Paediatric Haematologist, Great Ormond Street Hospital

Host: Professor Rahul Roychoudhuri, Professor of Cancer Immunology, University of Cambridge.

For anyone who can’t attend in person, please join the Cambridge Immunology and Medicine Seminar on Zoom Refreshments will be available following the Seminar.

This talk is part of the Immunology and Medicine Seminars series.

If you have a question about this talk, please contact Ruth Paton

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Wed 28 Feb 14:00: The complexed relationships of African Schistosoma species

Fri, 16/02/2024 - 10:26
The complexed relationships of African Schistosoma species

Abstract not available

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Tue 04 Jun 12:00: Title to be confirmed

Mon, 12/02/2024 - 11:00
Title to be confirmed

Abstract not available

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Tue 07 May 12:00: Title to be confirmed

Mon, 12/02/2024 - 11:00
Title to be confirmed

Abstract not available

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Tue 30 Apr 12:00: Title to be confirmed

Mon, 12/02/2024 - 10:59
Title to be confirmed

Abstract not available

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Tue 23 Apr 12:00: Tumor targeting: from encoded libraries to clinical-stage therapeutics

Mon, 12/02/2024 - 10:58
Tumor targeting: from encoded libraries to clinical-stage therapeutics

Abstract not available

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