Medicine

• I am a first year medical student looking to expand on research I conducted as an undergraduate at UCL and the Broad Institute in AMR evolution, largely considering the fitness costs of MGE carriage, and the evolutionary dynamics of these in both CRE and Staph Aureus.
• Key Projects:
  • Fitness costs and plasmid loss rates of carbapenemase encoding plasmids in Enterobacterales. (Bhattacharyya lab, Broad Institute)
  • Dynamics of blaZ in MRSA. (Murray group, UCL)

What I do:

I am using computational methods to functionally annotate bacterial genomes, using a variety of genome-scale "omics" data sets.

Research Interests:

• Functional genomics

What I do:

In the realm of infectious diseases, I'm currently focusing on microbial evolution, molecular diagnostics, and the effectiveness of vaccines and immunoglobulin therapy.

What I do:

My research interest is in host-pathogen interactions in the context of intracellular bacteria. My project looks at Orientia tsutsugamushi, a bacterium that causes scrub typhus and aims to identify the mechanisms by which Orientia tsutsugamushi differentiates from an intracellular to an extracellular state during its lifecycle in humans. I utilise proteomics and spatial transcriptomics to gain a global insight into the processes regulating different stages of Orientia tsutsugamushi infection.

Research Interests:

Most of my work is devoted to genomically characterising Salmonella Paratyphi A with a particular focus on AMR, virulence factors, phylogeny and global distribution of the pathogen. I am also interested in azithromycin resistance within S. Paratyphi A with a focus on the increase of resistance in low-mid-income countries.

What I do:

I am developing a 2D intestinal organoid monolayer model with macrophage co-culture to study intestinal barrier function and enteric commensal/pathogen interactions.

Research Interests:

• Host-pathogen interactions
• Novel alternatives to antibiotics
• Antimicrobial resistance