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An Interdisciplinary Research Centre at the University of Cambridge

Read more at: Alasdair Fletcher

Alasdair Fletcher

  • I am a first year medical student looking to expand on research I conducted as an undergraduate at UCL and the Broad Institute in AMR evolution, largely considering the fitness costs of MGE carriage, and the evolutionary dynamics of these in both CRE and Staph Aureus.
  • Key Projects:
    • Fitness costs and plasmid loss rates of carbapenemase encoding plasmids in Enterobacterales. (Bhattacharyya lab, Broad Institute)
    • Dynamics of blaZ in MRSA. (Murray group, UCL)

Read more at: Dr Adam Dinan

Dr Adam Dinan

What I do:

I am using computational methods to functionally annotate bacterial genomes, using a variety of genome-scale "omics" data sets.

Research Interests:

  • Functional genomics

Read more at: Dr Vignesh Shetty

Dr Vignesh Shetty

What I do:

In the realm of infectious diseases, I'm currently focusing on microbial evolution, molecular diagnostics, and the effectiveness of vaccines and immunoglobulin therapy.

Read more at: Rachel Jackson

Rachel Jackson

What I do:

My research interest is in host-pathogen interactions in the context of intracellular bacteria. My project looks at Orientia tsutsugamushi, a bacterium that causes scrub typhus and aims to identify the mechanisms by which Orientia tsutsugamushi differentiates from an intracellular to an extracellular state during its lifecycle in humans. I utilise proteomics and spatial transcriptomics to gain a global insight into the processes regulating different stages of Orientia tsutsugamushi infection.

Read more at: Joana Dias

Joana Dias

Research Interests:
Most of my work is devoted to genomically characterising Salmonella Paratyphi A with a particular focus on AMR, virulence factors, phylogeny and global distribution of the pathogen. I am also interested in azithromycin resistance within S. Paratyphi A with a focus on the increase of resistance in low-mid-income countries.