Medicine

What I do:

I am using computational methods to functionally annotate bacterial genomes, using a variety of genome-scale "omics" data sets.

Research Interests:

• Functional genomics

What I do:

In the realm of infectious diseases, I'm currently focusing on microbial evolution, molecular diagnostics, and the effectiveness of vaccines and immunoglobulin therapy.

What I do:

My research interest is in host-pathogen interactions in the context of intracellular bacteria. My project looks at Orientia tsutsugamushi, a bacterium that causes scrub typhus and aims to identify the mechanisms by which Orientia tsutsugamushi differentiates from an intracellular to an extracellular state during its lifecycle in humans. I utilise proteomics and spatial transcriptomics to gain a global insight into the processes regulating different stages of Orientia tsutsugamushi infection.

Research Interests:

Most of my work is devoted to genomically characterising Salmonella Paratyphi A with a particular focus on AMR, virulence factors, phylogeny and global distribution of the pathogen. I am also interested in azithromycin resistance within S. Paratyphi A with a focus on the increase of resistance in low-mid-income countries.

What I do:

I am developing a 2D intestinal organoid monolayer model with macrophage co-culture to study intestinal barrier function and enteric commensal/pathogen interactions.

Research Interests:

• Host-pathogen interactions
• Novel alternatives to antibiotics
• Antimicrobial resistance