Medicine

What I do:

I am using computational methods to functionally annotate bacterial genomes, using a variety of genome-scale "omics" data sets.

Research Interests:

• Functional genomics

What I do:

In the realm of infectious diseases, I'm currently focusing on microbial evolution, molecular diagnostics, and the effectiveness of vaccines and immunoglobulin therapy.

What I do:

I am interested in how the human genome defends itself from invaders such as viruses and retrotransposons. I am investigating how the HUman Silencing Hub (HUSH) is able to distinguish foreign DNA from our own genes, and the mechanism of silencing.

Research Interests:

Intracellular immunity, epigenetics, transcription, molecular biology, mathematical modelling.

Research Interests:

Most of my work is devoted to genomically characterising Salmonella Paratyphi A with a particular focus on AMR, virulence factors, phylogeny and global distribution of the pathogen. I am also interested in azithromycin resistance within S. Paratyphi A with a focus on the increase of resistance in low-mid-income countries.

What I do:

I am developing a 2D intestinal organoid monolayer model with macrophage co-culture to study intestinal barrier function and enteric commensal/pathogen interactions.

Research Interests:

• Host-pathogen interactions
• Novel alternatives to antibiotics
• Antimicrobial resistance

About my research:

I study adaptive immunity to pathogens, malignant cells and autoimmune diseases.

Caroline Zellmer is a microbiologist and PhD student based at the Cambridge Institute of Therapeutic Immunology and Infectious Disease within the Department of Medicine at the University of Cambridge. Her doctoral work will focus on using genomics and applied microbiology to better understand antimicrobial resistance in Klebsiella with the aim of developing novel or repurposing available therapeutics.