Medicine

What I do:

My research interest is in host-pathogen interactions in the context of intracellular bacteria. My project looks at Orientia tsutsugamushi, a bacterium that causes scrub typhus and aims to identify the mechanisms by which Orientia tsutsugamushi differentiates from an intracellular to an extracellular state during its lifecycle in humans. I utilise proteomics and spatial transcriptomics to gain a global insight into the processes regulating different stages of Orientia tsutsugamushi infection.

Research Interests:

Most of my work is devoted to genomically characterising Salmonella Paratyphi A with a particular focus on AMR, virulence factors, phylogeny and global distribution of the pathogen. I am also interested in azithromycin resistance within S. Paratyphi A with a focus on the increase of resistance in low-mid-income countries.

What I do:

I am developing a 2D intestinal organoid monolayer model with macrophage co-culture to study intestinal barrier function and enteric commensal/pathogen interactions.

Research Interests:

• Host-pathogen interactions
• Novel alternatives to antibiotics
• Antimicrobial resistance

About my research:

I study adaptive immunity to pathogens, malignant cells and autoimmune diseases.

Caroline Zellmer is a microbiologist and PhD student based at the Cambridge Institute of Therapeutic Immunology and Infectious Disease within the Department of Medicine at the University of Cambridge. Her doctoral work will focus on using genomics and applied microbiology to better understand antimicrobial resistance in Klebsiella with the aim of developing novel or repurposing available therapeutics.

What do I do?

I am working on typhoidal Salmonella with a focus on Salmonella paratyphi A trying to identify good vaccine candidates and antimicrobial therapies. In my projects, we collaborate with GSK Siena, NIBSC, and CRUK.

What do I do?

• I manage & provide regulatory/governance support for vaccine trials and other clinical research in LMICs.

Key projects:

What do I do?

I am currently working on a rapid diagnostics project for respiratory infection in critically ill children that require intensive care. My key projects are: