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An Interdisciplinary Research Centre at the University of Cambridge


Effrossyni Gkrania-Klotsas is a Consultant in infectious Diseases with an interest in primary and secondary immunodeficiencies and transplantation at Cambridge University Hospitals in Cambridge, UK.
She is a board certified practitioner of infectious diseases and internal medicine by the American Board of Internal Medicine (ABIM), a Fellow of the Royal College of Physicians (FRCP), a Fellow of St Edmund's college and an associate lecturer of the University of Cambridge.
She has conducted a PhD on the associations of chronic viral infections and cardiovascular disease, diabetes and mortality. She has additionally completed postgraduate studies in Public health as well as Medical Education and Medical Genomics. She is inviting collaborations from colleagues interested in hospital epidemiology, treating complex patients, novel diagnostics, emerging infectious diseases and clinical trials.

She is particularly interested in mentoring students, trainees and scientists starting their careers.


Currently interested in the diverse clinical presentations of infections in immune deficiency, developing clinical standards and diagnostics for infections in immune deficiency and increasing awareness in AMR.

She is inviting collaborations from colleagues interested in hospital epidemiology, treating complex patients, novel diagnostics, emerging infectious diseases and clinical trials.

She is particularly interested in mentoring students, trainees and scientists starting their careers.


Key publications: 


1: Cottle LE, Gkrania-Klotsas E, Williams HJ, Brindle HE, Carmichael AJ, Fry G,

Beeching NJ. A multinational outbreak of histoplasmosis following a biology field

trip in the ugandan rainforest. J Travel Med. 2013 Mar;20(2):83-7. doi:

10.1111/jtm.12012. Epub 2013 Jan 30. PubMed PMID: 23464714.



2: Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ.

Seropositivity and higher IgG antibody levels against Cytomegalovirus are

associated with mortality in the population based EPIC-Norfolk cohort. Clin

Infect Dis. 2013 Feb 26. [Epub ahead of print] PubMed PMID: 23442763.



3: Bloomfield MG, Carmichael AJ, Gkrania-Klotsas E. Mortality in Clostridium

difficile infection: a prospective analysis of risk predictors. Eur J

Gastroenterol Hepatol. 2013 Feb 24. [Epub ahead of print] PubMed PMID: 23442414.



4: Lim PL, Han P, Chen LH, MacDonald S, Pandey P, Hale D, Schlagenhauf P, Loutan

L, Wilder-Smith A, Davis XM, Freedman DO; GeoSentinel Surveillance Network.

Expatriates ill after travel: results from the Geosentinel Surveillance Network.

BMC Infect Dis. 2012 Dec 31;12:386. doi: 10.1186/1471-2334-12-386. PubMed PMID:




5: Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ.

Higher immunoglobulin G antibody levels against cytomegalovirus are associated

with incident ischemic heart disease in the population-based EPIC-Norfolk cohort.

J Infect Dis. 2012 Dec 15;206(12):1897-903. doi: 10.1093/infdis/jis620. Epub 2012

Oct 8. PubMed PMID: 23045624.



6: Gautret P, Cramer JP, Field V, Caumes E, Jensenius M, Gkrania-Klotsas E, de

Vries PJ, Grobusch MP, Lopez-Velez R, Castelli F, Schlagenhauf P, Hervius Askling

H, von Sonnenburg F, Lalloo DG, Loutan L, Rapp C, Basto F, Santos O'Connor F,

Weld L, Parola P; EuroTravNet Network. Infectious diseases among travellers and

migrants in Europe, EuroTravNet 2010. Euro Surveill. 2012 Jun 28;17(26). doi:pii:

20205. PubMed PMID: 22790534.



7: Bloomfield MG, Sherwin JC, Gkrania-Klotsas E. Risk factors for mortality in

Clostridium difficile infection in the general hospital population: a systematic

review. J Hosp Infect. 2012 Sep;82(1):1-12. doi: 10.1016/j.jhin.2012.05.008. Epub

2012 Jun 22. Review. PubMed PMID: 22727824.



8: Esposito DH, Han PV, Kozarsky PE, Walker PF, Gkrania-Klotsas E, Barnett ED,

Libman M, McCarthy AE, Field V, Connor BA, Schwartz E, MacDonald S, Sotir MJ;

GeoSentinel Surveillance Network. Characteristics and spectrum of disease among

ill returned travelers from pre- and post-earthquake Haiti: The GeoSentinel

experience. Am J Trop Med Hyg. 2012 Jan;86(1):23-8. doi:

10.4269/ajtmh.2012.11-0430. PubMed PMID: 22232445; PubMed Central PMCID:




9: Gkrania-Klotsas E, Langenberg C, Tauriainen S, Sharp SJ, Luben R, Forouhi NG,

Khaw KT, Hyöty H, Wareham NJ. The association between prior infection with five

serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the

EPIC-Norfolk study. Diabetologia. 2012 Apr;55(4):967-70. doi:

10.1007/s00125-011-2443-7. Epub 2012 Jan 10. PubMed PMID: 22231126.



10: Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A,

Franceschi C, Fulop T, Gkrania-Klotsas E, Goronzy J, Griffiths SJ, Henson S,

Herndler-Brandstetter D, Hill A, Kern F, Klenerman P, Macallan D, Macualay R,

Maier AB, Mason G, Melzer D, Morgan M, Moss P, Nikolich-Zugich J, Pachnio A,

Riddell N, Roberts R, Sansoni P, Sauce D, Sinclair J, Solana R, Strindhall J,

Trzonkowski P, van Lier R, Vescovini R, Wang G, Westendorp R, Pawelec G. Report

from the second cytomegalovirus and immunosenescence workshop. Immun Ageing. 2011

Oct 28;8(1):10. doi: 10.1186/1742-4933-8-10. PubMed PMID: 22035114; PubMed

Central PMCID: PMC3222598.



11: Odolini S, Parola P, Gkrania-Klotsas E, Caumes E, Schlagenhauf P, López-Vélez

R, Burchard GD, Santos-O'Connor F, Weld L, von Sonnenburg F, Field V, de Vries P,

Jensenius M, Loutan L, Castelli F. Travel-related imported infections in Europe,

EuroTravNet 2009. Clin Microbiol Infect. 2012 May;18(5):468-74. doi:

10.1111/j.1469-0691.2011.03596.x. Epub 2011 Aug 16. PubMed PMID: 21848975.



12: Flores-Figueroa J, Okhuysen PC, von Sonnenburg F, DuPont HL, Libman MD,

Keystone JS, Hale DC, Burchard G, Han PV, Wilder-Smith A, Freedman DO;

GeoSentinel Surveillance Network. Patterns of illness in travelers visiting

Mexico and Central America: the GeoSentinel experience. Clin Infect Dis. 2011

Sep;53(6):523-31. doi: 10.1093/cid/cir468. Epub 2011 Aug 10. PubMed PMID:




13: Molloy A, Matheson NJ, Meyer PA, Chaterjee K, Gkrania-Klotsas E. Cushing's

syndrome and adrenal axis suppression in a patient treated with ritonavir and

corticosteroid eye drops. AIDS. 2011 Jun 19;25(10):1337-9. doi:

10.1097/QAD.0b013e328347c09c. PubMed PMID: 21659797.



14: Thwaites GE, Edgeworth JD, Gkrania-Klotsas E, Kirby A, Tilley R, Török ME,

Walker S, Wertheim HF, Wilson P, Llewelyn MJ; UK Clinical Infection Research

Group. Clinical management of Staphylococcus aureus bacteraemia. Lancet Infect

Dis. 2011 Mar;11(3):208-22. doi: 10.1016/S1473-3099(10)70285-1. Review. PubMed

PMID: 21371655.



15: Thwaites GE; United Kingdom Clinical Infection Research Group (UKCIRG). The

management of Staphylococcus aureus bacteremia in the United Kingdom and Vietnam:

a multi-centre evaluation. PLoS One. 2010 Dec 13;5(12):e14170. doi:

10.1371/journal.pone.0014170. PubMed PMID: 21179193; PubMed Central PMCID:




16: Field V, Gautret P, Schlagenhauf P, Burchard GD, Caumes E, Jensenius M,

Castelli F, Gkrania-Klotsas E, Weld L, Lopez-Velez R, de Vries P, von Sonnenburg

F, Loutan L, Parola P; EuroTravNet network. Travel and migration associated

infectious diseases morbidity in Europe, 2008. BMC Infect Dis. 2010 Nov

17;10:330. doi: 10.1186/1471-2334-10-330. PubMed PMID: 21083874; PubMed Central

PMCID: PMC3001727.



17: Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen LK,

Gokulakrishnan K, Hanefeld M, Ingelsson E, Lai WA, Lin SY, Lind L, Lohsoonthorn

V, Mohan V, Muscari A, Nilsson G, Ohrvik J, Chao Qiang J, Jenny NS, Tamakoshi K,

Temelkova-Kurktschiev T, Wang YY, Yajnik CS, Zoli M, Khaw KT, Forouhi NG, Wareham

NJ, Langenberg C. Differential white blood cell count and type 2 diabetes:

systematic review and meta-analysis of cross-sectional and prospective studies.

PLoS One. 2010 Oct 18;5(10):e13405. doi: 10.1371/journal.pone.0013405.

PubMed PMID: 20976133; PubMed Central PMCID: PMC2956635.



18: Boggild AK, Castelli F, Gautret P, Torresi J, von Sonnenburg F, Barnett ED,

Greenaway CA, Lim PL, Schwartz E, Wilder-Smith A, Wilson ME; GeoSentinel

Surveillance Network. Vaccine preventable diseases in returned international

travelers: results from the GeoSentinel Surveillance Network. Vaccine. 2010 Oct

28;28(46):7389-95. doi: 10.1016/j.vaccine.2010.09.009. Epub 2010 Sep 17. PubMed

PMID: 20851081.



19: Mendelson M, Davis XM, Jensenius M, Keystone JS, von Sonnenburg F, Hale DC,

Burchard GD, Field V, Vincent P, Freedman DO; GeoSentinel Surveillance Network.

Health risks in travelers to South Africa: the GeoSentinel experience and

implications for the 2010 FIFA World Cup. Am J Trop Med Hyg. 2010

Jun;82(6):991-5. doi: 10.4269/ajtmh.2010.10-0198. PubMed PMID: 20519590.



20: Parks T, Gkrania-Klotsas E, Nicholl C. Treatment with monoclonal antibodies

against Clostridium difficile toxins. N Engl J Med. 2010 Apr 15;362(15):1444;

author reply 1445-6. doi: 10.1056/NEJMc1002213. PubMed PMID: 20393181.



21: Hagmann S, Neugebauer R, Schwartz E, Perret C, Castelli F, Barnett ED,

Stauffer WM; GeoSentinel Surveillance Network. Illness in children after

international travel: analysis from the GeoSentinel Surveillance Network.

Pediatrics. 2010 May;125(5):e1072-80. doi: 10.1542/peds.2009-1951. Epub 2010 Apr

5. PubMed PMID: 20368323.





22: Schlagenhauf P, Chen LH, Wilson ME, Freedman DO, Tcheng D, Schwartz E, Pandey

P, Weber R, Nadal D, Berger C, von Sonnenburg F, Keystone J, Leder K; GeoSentinel

Surveillance Network. Sex and gender differences in travel-associated disease.

Clin Infect Dis. 2010 Mar 15;50(6):826-32. doi: 10.1086/650575. PubMed PMID:




23: Parks T, Wallis S, Wilson J, Gkrania-Klotsas E, Nicholl C. Continuing

diarrhoea after ten days of oral metronidazole or oral vancomycin for presumed,

hospital-acquired Clostridium difficile colitis in elderly hospital patients. J

Hosp Infect. 2010 Apr;74(4):403-5. doi: 10.1016/j.jhin.2009.11.002. Epub 2010 Feb

12. PubMed PMID: 20153080.



24: Cooke FJ, Gkrania-Klotsas E. Clostridium difficile infection: more known than

is realised. Ann R Coll Surg Engl. 2010 Jan;92(1):89; author reply 89-90. doi:

10.1308/003588410X12518836439849. PubMed PMID: 20056074.



25: Cooke FJ, Gkrania-Klotsas E, Howard JC, Stone M, Kearns AM, Ganner M,

Carmichael AJ, Brown NM. Clinical, molecular and epidemiological description of a

cluster of community-associated methicillin-resistant Staphylococcus aureus

isolates from injecting drug users with bacteraemia. Clin Microbiol Infect. 2010

Jul;16(7):921-6. doi: 10.1111/j.1469-0691.2009.02969.x. Epub 2009 Nov 11. PubMed

PMID: 19912266.



26: Jensenius M, Davis X, von Sonnenburg F, Schwartz E, Keystone JS, Leder K,

Lopéz-Véléz R, Caumes E, Cramer JP, Chen L, Parola P; GeoSentinel Surveillance

Network. Multicenter GeoSentinel analysis of rickettsial diseases in

international travelers, 1996-2008. Emerg Infect Dis. 2009 Nov;15(11):1791-8.

doi: 10.3201/eid1511.090677. PubMed PMID: 19891867.



27: Gautret P, Schlagenhauf P, Gaudart J, Castelli F, Brouqui P, von Sonnenburg

F, Loutan L, Parola P; GeoSentinel Surveillance Network. Multicenter

EuroTravNet/GeoSentinel study of travel-related infectious diseases in Europe.

Emerg Infect Dis. 2009 Nov;15(11):1783-90. doi: 10.3201/eid1511.091147. PubMed

PMID: 19891866.



28: Chen LH, Wilson ME, Davis X, Loutan L, Schwartz E, Keystone J, Hale D, Lim

PL, McCarthy A, Gkrania-Klotsas E, Schlagenhauf P; GeoSentinel Surveillance

Network. Illness in long-term travelers visiting GeoSentinel clinics. Emerg

Infect Dis. 2009 Nov;15(11):1773-82. doi: 10.3201/eid1511.090945. PubMed PMID:




29: Pollock E, Klotsas AE, Compston J, Gkrania-Klotsas E. Bone health in HIV

infection. Br Med Bull. 2009;92:123-33. doi: 10.1093/bmb/ldp037. Epub . Review.

PubMed PMID: 19875393.



30: Tsagkaraki AP, Sampaziotis F, Cooke FJ, Gkrania-Klotsas E. Assessing staff

knowledge about Clostridium difficile diarrhoea. J Hosp Infect. 2009

May;72(1):81-3. doi: 10.1016/j.jhin.2009.02.006. Epub 2009 Mar 12. PubMed PMID:




31: Gkrania-Klotsas E, Cooke FJ, Zochios V, Lofitou N. Fever, a blue hand, and

abducens nerve paralysis in a returning traveler. J Travel Med. 2009

Jan-Feb;16(1):57-9. doi: 10.1111/j.1708-8305.2008.00262.x. PubMed PMID: 19192131.



32: Connick RM, Connick P, Klotsas AE, Tsagkaraki PA, Gkrania-Klotsas E.

Procedural confidence in hospital based practitioners: implications for the

training and practice of doctors at all grades. BMC Med Educ. 2009 Jan 12;9:2.

doi: 10.1186/1472-6920-9-2. PubMed PMID: 19138395.



33: Weekes M, Matheson N, Coggle S, Gkrania-Klotsas E. Furuncular myiasis. BMJ

Case Rep. 2009;2009. doi:pii: bcr06.2009.2026. 10.1136/bcr.06.2009.2026. Epub

2009 Aug 25. PubMed PMID: 21866234.



34: Gkrania-Klotsas E, Lever AM. Herpes simplex I encephalitis presenting as a

brain haemorrhage with normal cerebrospinal fluid analysis: a case report. J Med

Case Rep. 2008 Dec 17;2:387. doi: 10.1186/1752-1947-2-387. PubMed PMID: 19091062.



35: Nicolls DJ, Weld LH, Schwartz E, Reed C, von Sonnenburg F, Freedman DO,

Kozarsky PE; GeoSentinel Surveillance Network. Characteristics of schistosomiasis

in travelers reported to the GeoSentinel Surveillance Network 1997-2008. Am J

Trop Med Hyg. 2008 Nov;79(5):729-34. PubMed PMID: 18981513.



36: Gkrania-Klotsas E, Klotsas AE. HIV and HIV treatment: effects on fats,

glucose and lipids. Br Med Bull. 2007;84:49-68. Epub 2007 Nov 2. Review. PubMed

PMID: 17981955.



37: Gkrania-Klotsas E, Hershow RC. Colonization or infection with

multidrug-resistant Acinetobacter baumannii may be an independent risk factor for

increased mortality. Clin Infect Dis. 2006 Nov 1;43(9):1224-5. PubMed PMID:




38: Gkrania-Klotsas E, Lever AM. An update on malaria prevention, diagnosis and

treatment for the returning traveller. Blood Rev. 2007 Mar;21(2):73-87. Epub 2006

Jul 3. Review. PubMed PMID: 16815604.



39: Gkrania-Klotsas E, Lever AM. A husband and wife with left hand rashes. Lancet

Infect Dis. 2005 Dec;5(12):802. PubMed PMID: 16310152.


A consultant in infectious diseases with an interest in primary and secondary immunodeficiencies and transplantation.
Dr Effrossyni  Gkrania - Klotsas

Contact Details

Box 25
Addenbrooke's Hospital
Hills Road
Available for consultancy