Biography
Effrossyni Gkrania-Klotsas is a Consultant in infectious Diseases with an interest in primary and secondary immunodeficiencies and transplantation at Cambridge University Hospitals in Cambridge, UK.
She is a board certified practitioner of infectious diseases and internal medicine by the American Board of Internal Medicine (ABIM), a Fellow of the Royal College of Physicians (FRCP), a Fellow of St Edmund's college and an associate lecturer of the University of Cambridge.
She has conducted a PhD on the associations of chronic viral infections and cardiovascular disease, diabetes and mortality. She has additionally completed postgraduate studies in Public health as well as Medical Education and Medical Genomics. She is inviting collaborations from colleagues interested in hospital epidemiology, treating complex patients, novel diagnostics, emerging infectious diseases and clinical trials.
She is particularly interested in mentoring students, trainees and scientists starting their careers.
Research
Currently interested in the diverse clinical presentations of infections in immune deficiency, developing clinical standards and diagnostics for infections in immune deficiency and increasing awareness in AMR.
She is inviting collaborations from colleagues interested in hospital epidemiology, treating complex patients, novel diagnostics, emerging infectious diseases and clinical trials.
She is particularly interested in mentoring students, trainees and scientists starting their careers.
Publications
1: Cottle LE, Gkrania-Klotsas E, Williams HJ, Brindle HE, Carmichael AJ, Fry G,
Beeching NJ. A multinational outbreak of histoplasmosis following a biology field
trip in the ugandan rainforest. J Travel Med. 2013 Mar;20(2):83-7. doi:
10.1111/jtm.12012. Epub 2013 Jan 30. PubMed PMID: 23464714.
2: Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ.
Seropositivity and higher IgG antibody levels against Cytomegalovirus are
associated with mortality in the population based EPIC-Norfolk cohort. Clin
Infect Dis. 2013 Feb 26. [Epub ahead of print] PubMed PMID: 23442763.
3: Bloomfield MG, Carmichael AJ, Gkrania-Klotsas E. Mortality in Clostridium
difficile infection: a prospective analysis of risk predictors. Eur J
Gastroenterol Hepatol. 2013 Feb 24. [Epub ahead of print] PubMed PMID: 23442414.
4: Lim PL, Han P, Chen LH, MacDonald S, Pandey P, Hale D, Schlagenhauf P, Loutan
L, Wilder-Smith A, Davis XM, Freedman DO; GeoSentinel Surveillance Network.
Expatriates ill after travel: results from the Geosentinel Surveillance Network.
BMC Infect Dis. 2012 Dec 31;12:386. doi: 10.1186/1471-2334-12-386. PubMed PMID:
23273048.
5: Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw KT, Wareham NJ.
Higher immunoglobulin G antibody levels against cytomegalovirus are associated
with incident ischemic heart disease in the population-based EPIC-Norfolk cohort.
J Infect Dis. 2012 Dec 15;206(12):1897-903. doi: 10.1093/infdis/jis620. Epub 2012
Oct 8. PubMed PMID: 23045624.
6: Gautret P, Cramer JP, Field V, Caumes E, Jensenius M, Gkrania-Klotsas E, de
Vries PJ, Grobusch MP, Lopez-Velez R, Castelli F, Schlagenhauf P, Hervius Askling
H, von Sonnenburg F, Lalloo DG, Loutan L, Rapp C, Basto F, Santos O'Connor F,
Weld L, Parola P; EuroTravNet Network. Infectious diseases among travellers and
migrants in Europe, EuroTravNet 2010. Euro Surveill. 2012 Jun 28;17(26). doi:pii:
20205. PubMed PMID: 22790534.
7: Bloomfield MG, Sherwin JC, Gkrania-Klotsas E. Risk factors for mortality in
Clostridium difficile infection in the general hospital population: a systematic
review. J Hosp Infect. 2012 Sep;82(1):1-12. doi: 10.1016/j.jhin.2012.05.008. Epub
2012 Jun 22. Review. PubMed PMID: 22727824.
8: Esposito DH, Han PV, Kozarsky PE, Walker PF, Gkrania-Klotsas E, Barnett ED,
Libman M, McCarthy AE, Field V, Connor BA, Schwartz E, MacDonald S, Sotir MJ;
GeoSentinel Surveillance Network. Characteristics and spectrum of disease among
ill returned travelers from pre- and post-earthquake Haiti: The GeoSentinel
experience. Am J Trop Med Hyg. 2012 Jan;86(1):23-8. doi:
10.4269/ajtmh.2012.11-0430. PubMed PMID: 22232445; PubMed Central PMCID:
PMC3247103.
9: Gkrania-Klotsas E, Langenberg C, Tauriainen S, Sharp SJ, Luben R, Forouhi NG,
Khaw KT, Hyöty H, Wareham NJ. The association between prior infection with five
serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the
EPIC-Norfolk study. Diabetologia. 2012 Apr;55(4):967-70. doi:
10.1007/s00125-011-2443-7. Epub 2012 Jan 10. PubMed PMID: 22231126.
10: Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A,
Franceschi C, Fulop T, Gkrania-Klotsas E, Goronzy J, Griffiths SJ, Henson S,
Herndler-Brandstetter D, Hill A, Kern F, Klenerman P, Macallan D, Macualay R,
Maier AB, Mason G, Melzer D, Morgan M, Moss P, Nikolich-Zugich J, Pachnio A,
Riddell N, Roberts R, Sansoni P, Sauce D, Sinclair J, Solana R, Strindhall J,
Trzonkowski P, van Lier R, Vescovini R, Wang G, Westendorp R, Pawelec G. Report
from the second cytomegalovirus and immunosenescence workshop. Immun Ageing. 2011
Oct 28;8(1):10. doi: 10.1186/1742-4933-8-10. PubMed PMID: 22035114; PubMed
Central PMCID: PMC3222598.
11: Odolini S, Parola P, Gkrania-Klotsas E, Caumes E, Schlagenhauf P, López-Vélez
R, Burchard GD, Santos-O'Connor F, Weld L, von Sonnenburg F, Field V, de Vries P,
Jensenius M, Loutan L, Castelli F. Travel-related imported infections in Europe,
EuroTravNet 2009. Clin Microbiol Infect. 2012 May;18(5):468-74. doi:
10.1111/j.1469-0691.2011.03596.x. Epub 2011 Aug 16. PubMed PMID: 21848975.
12: Flores-Figueroa J, Okhuysen PC, von Sonnenburg F, DuPont HL, Libman MD,
Keystone JS, Hale DC, Burchard G, Han PV, Wilder-Smith A, Freedman DO;
GeoSentinel Surveillance Network. Patterns of illness in travelers visiting
Mexico and Central America: the GeoSentinel experience. Clin Infect Dis. 2011
Sep;53(6):523-31. doi: 10.1093/cid/cir468. Epub 2011 Aug 10. PubMed PMID:
21832261.
13: Molloy A, Matheson NJ, Meyer PA, Chaterjee K, Gkrania-Klotsas E. Cushing's
syndrome and adrenal axis suppression in a patient treated with ritonavir and
corticosteroid eye drops. AIDS. 2011 Jun 19;25(10):1337-9. doi:
10.1097/QAD.0b013e328347c09c. PubMed PMID: 21659797.
14: Thwaites GE, Edgeworth JD, Gkrania-Klotsas E, Kirby A, Tilley R, Török ME,
Walker S, Wertheim HF, Wilson P, Llewelyn MJ; UK Clinical Infection Research
Group. Clinical management of Staphylococcus aureus bacteraemia. Lancet Infect
Dis. 2011 Mar;11(3):208-22. doi: 10.1016/S1473-3099(10)70285-1. Review. PubMed
PMID: 21371655.
15: Thwaites GE; United Kingdom Clinical Infection Research Group (UKCIRG). The
management of Staphylococcus aureus bacteremia in the United Kingdom and Vietnam:
a multi-centre evaluation. PLoS One. 2010 Dec 13;5(12):e14170. doi:
10.1371/journal.pone.0014170. PubMed PMID: 21179193; PubMed Central PMCID:
PMC3001442.
16: Field V, Gautret P, Schlagenhauf P, Burchard GD, Caumes E, Jensenius M,
Castelli F, Gkrania-Klotsas E, Weld L, Lopez-Velez R, de Vries P, von Sonnenburg
F, Loutan L, Parola P; EuroTravNet network. Travel and migration associated
infectious diseases morbidity in Europe, 2008. BMC Infect Dis. 2010 Nov
17;10:330. doi: 10.1186/1471-2334-10-330. PubMed PMID: 21083874; PubMed Central
PMCID: PMC3001727.
17: Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen LK,
Gokulakrishnan K, Hanefeld M, Ingelsson E, Lai WA, Lin SY, Lind L, Lohsoonthorn
V, Mohan V, Muscari A, Nilsson G, Ohrvik J, Chao Qiang J, Jenny NS, Tamakoshi K,
Temelkova-Kurktschiev T, Wang YY, Yajnik CS, Zoli M, Khaw KT, Forouhi NG, Wareham
NJ, Langenberg C. Differential white blood cell count and type 2 diabetes:
systematic review and meta-analysis of cross-sectional and prospective studies.
PLoS One. 2010 Oct 18;5(10):e13405. doi: 10.1371/journal.pone.0013405.
PubMed PMID: 20976133; PubMed Central PMCID: PMC2956635.
18: Boggild AK, Castelli F, Gautret P, Torresi J, von Sonnenburg F, Barnett ED,
Greenaway CA, Lim PL, Schwartz E, Wilder-Smith A, Wilson ME; GeoSentinel
Surveillance Network. Vaccine preventable diseases in returned international
travelers: results from the GeoSentinel Surveillance Network. Vaccine. 2010 Oct
28;28(46):7389-95. doi: 10.1016/j.vaccine.2010.09.009. Epub 2010 Sep 17. PubMed
PMID: 20851081.
19: Mendelson M, Davis XM, Jensenius M, Keystone JS, von Sonnenburg F, Hale DC,
Burchard GD, Field V, Vincent P, Freedman DO; GeoSentinel Surveillance Network.
Health risks in travelers to South Africa: the GeoSentinel experience and
implications for the 2010 FIFA World Cup. Am J Trop Med Hyg. 2010
Jun;82(6):991-5. doi: 10.4269/ajtmh.2010.10-0198. PubMed PMID: 20519590.
20: Parks T, Gkrania-Klotsas E, Nicholl C. Treatment with monoclonal antibodies
against Clostridium difficile toxins. N Engl J Med. 2010 Apr 15;362(15):1444;
author reply 1445-6. doi: 10.1056/NEJMc1002213. PubMed PMID: 20393181.
21: Hagmann S, Neugebauer R, Schwartz E, Perret C, Castelli F, Barnett ED,
Stauffer WM; GeoSentinel Surveillance Network. Illness in children after
international travel: analysis from the GeoSentinel Surveillance Network.
Pediatrics. 2010 May;125(5):e1072-80. doi: 10.1542/peds.2009-1951. Epub 2010 Apr
5. PubMed PMID: 20368323.
22: Schlagenhauf P, Chen LH, Wilson ME, Freedman DO, Tcheng D, Schwartz E, Pandey
P, Weber R, Nadal D, Berger C, von Sonnenburg F, Keystone J, Leder K; GeoSentinel
Surveillance Network. Sex and gender differences in travel-associated disease.
Clin Infect Dis. 2010 Mar 15;50(6):826-32. doi: 10.1086/650575. PubMed PMID:
20156059.
23: Parks T, Wallis S, Wilson J, Gkrania-Klotsas E, Nicholl C. Continuing
diarrhoea after ten days of oral metronidazole or oral vancomycin for presumed,
hospital-acquired Clostridium difficile colitis in elderly hospital patients. J
Hosp Infect. 2010 Apr;74(4):403-5. doi: 10.1016/j.jhin.2009.11.002. Epub 2010 Feb
12. PubMed PMID: 20153080.
24: Cooke FJ, Gkrania-Klotsas E. Clostridium difficile infection: more known than
is realised. Ann R Coll Surg Engl. 2010 Jan;92(1):89; author reply 89-90. doi:
10.1308/003588410X12518836439849. PubMed PMID: 20056074.
25: Cooke FJ, Gkrania-Klotsas E, Howard JC, Stone M, Kearns AM, Ganner M,
Carmichael AJ, Brown NM. Clinical, molecular and epidemiological description of a
cluster of community-associated methicillin-resistant Staphylococcus aureus
isolates from injecting drug users with bacteraemia. Clin Microbiol Infect. 2010
Jul;16(7):921-6. doi: 10.1111/j.1469-0691.2009.02969.x. Epub 2009 Nov 11. PubMed
PMID: 19912266.
26: Jensenius M, Davis X, von Sonnenburg F, Schwartz E, Keystone JS, Leder K,
Lopéz-Véléz R, Caumes E, Cramer JP, Chen L, Parola P; GeoSentinel Surveillance
Network. Multicenter GeoSentinel analysis of rickettsial diseases in
international travelers, 1996-2008. Emerg Infect Dis. 2009 Nov;15(11):1791-8.
doi: 10.3201/eid1511.090677. PubMed PMID: 19891867.
27: Gautret P, Schlagenhauf P, Gaudart J, Castelli F, Brouqui P, von Sonnenburg
F, Loutan L, Parola P; GeoSentinel Surveillance Network. Multicenter
EuroTravNet/GeoSentinel study of travel-related infectious diseases in Europe.
Emerg Infect Dis. 2009 Nov;15(11):1783-90. doi: 10.3201/eid1511.091147. PubMed
PMID: 19891866.
28: Chen LH, Wilson ME, Davis X, Loutan L, Schwartz E, Keystone J, Hale D, Lim
PL, McCarthy A, Gkrania-Klotsas E, Schlagenhauf P; GeoSentinel Surveillance
Network. Illness in long-term travelers visiting GeoSentinel clinics. Emerg
Infect Dis. 2009 Nov;15(11):1773-82. doi: 10.3201/eid1511.090945. PubMed PMID:
19891865.
29: Pollock E, Klotsas AE, Compston J, Gkrania-Klotsas E. Bone health in HIV
infection. Br Med Bull. 2009;92:123-33. doi: 10.1093/bmb/ldp037. Epub . Review.
PubMed PMID: 19875393.
30: Tsagkaraki AP, Sampaziotis F, Cooke FJ, Gkrania-Klotsas E. Assessing staff
knowledge about Clostridium difficile diarrhoea. J Hosp Infect. 2009
May;72(1):81-3. doi: 10.1016/j.jhin.2009.02.006. Epub 2009 Mar 12. PubMed PMID:
19282050.
31: Gkrania-Klotsas E, Cooke FJ, Zochios V, Lofitou N. Fever, a blue hand, and
abducens nerve paralysis in a returning traveler. J Travel Med. 2009
Jan-Feb;16(1):57-9. doi: 10.1111/j.1708-8305.2008.00262.x. PubMed PMID: 19192131.
32: Connick RM, Connick P, Klotsas AE, Tsagkaraki PA, Gkrania-Klotsas E.
Procedural confidence in hospital based practitioners: implications for the
training and practice of doctors at all grades. BMC Med Educ. 2009 Jan 12;9:2.
doi: 10.1186/1472-6920-9-2. PubMed PMID: 19138395.
33: Weekes M, Matheson N, Coggle S, Gkrania-Klotsas E. Furuncular myiasis. BMJ
Case Rep. 2009;2009. doi:pii: bcr06.2009.2026. 10.1136/bcr.06.2009.2026. Epub
2009 Aug 25. PubMed PMID: 21866234.
34: Gkrania-Klotsas E, Lever AM. Herpes simplex I encephalitis presenting as a
brain haemorrhage with normal cerebrospinal fluid analysis: a case report. J Med
Case Rep. 2008 Dec 17;2:387. doi: 10.1186/1752-1947-2-387. PubMed PMID: 19091062.
35: Nicolls DJ, Weld LH, Schwartz E, Reed C, von Sonnenburg F, Freedman DO,
Kozarsky PE; GeoSentinel Surveillance Network. Characteristics of schistosomiasis
in travelers reported to the GeoSentinel Surveillance Network 1997-2008. Am J
Trop Med Hyg. 2008 Nov;79(5):729-34. PubMed PMID: 18981513.
36: Gkrania-Klotsas E, Klotsas AE. HIV and HIV treatment: effects on fats,
glucose and lipids. Br Med Bull. 2007;84:49-68. Epub 2007 Nov 2. Review. PubMed
PMID: 17981955.
37: Gkrania-Klotsas E, Hershow RC. Colonization or infection with
multidrug-resistant Acinetobacter baumannii may be an independent risk factor for
increased mortality. Clin Infect Dis. 2006 Nov 1;43(9):1224-5. PubMed PMID:
17029151.
38: Gkrania-Klotsas E, Lever AM. An update on malaria prevention, diagnosis and
treatment for the returning traveller. Blood Rev. 2007 Mar;21(2):73-87. Epub 2006
Jul 3. Review. PubMed PMID: 16815604.
39: Gkrania-Klotsas E, Lever AM. A husband and wife with left hand rashes. Lancet
Infect Dis. 2005 Dec;5(12):802. PubMed PMID: 16310152.
