Research
My research vision involves using viruses as tools to understand the nature of molecular immunity and cell biology. Important scientific insights into innate immunity and cell metabolism have been gleaned by studying host proteins involved in HIV replication. Such proteins often have central cellular roles and are therefore relevant for physiological processes and pathogenesis of other diseases, including cancer.
I characterise host-pathogen interactions in retrovirus systems on a molecular and genetic level to further our knowledge of innate immunity and cell biology, and to provide novel therapeutic targets. I am focusing on one established, and one newly described, antiviral protein.
Publications
Key publications:
- Groom HC1,Arnold LH1, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, Howell SA, Stoye JP, Webb M, Taylor IA, Bishop KN Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction 2015 PLoS Pathog11(10):e1005194
- Schwefel D, Groom HCT, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN & Taylor IA Structural basis of lentiviral subversion of a cellular protein degradation pathway 2014 Nature505(7482):234-8
Other publications:
- Ordonez P, Kunzelmann S, Groom HCT, Yap M, Weising S, Meier C, Bishop KN, Taylor IA SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells 2017 Sci Rep 7:42824
- Groom HCT, Warren AY, Neal DE, Bishop KN No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses 2012 PLoS One 7(3):e34221
- Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, de Carvalho LP, Stoye JP, Crow YJ, Taylor IA, Webb M HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. 2011 Nature 480(7377):379-82
- Groom HCT, Yap MW, Galão RP, Neil SJ, Bishop KN Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors2010 Proc Natl Acad Sci U S A107(11):5166-71
- Groom HCT, Boucherit VC, Makinson K, Randal E, Baptista S, Hagan S, Gow JW, Mattes FM, Breuer J, Kerr JR, Stoye JP, Bishop KN Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome2010 Retrovirology 7:10
- Groom HCT, Anderson EC, Dangerfield J, Lever AM Rev regulates translation of Human Immunodeficiency Virus Type-1 RNAs.2009 J Gen Virol 90(Pt 5):1141-7
- Gooding C, Clark F, Wollerton MC, Grellscheid SN, Groom H, Smith CWA class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones 2006 Genome Biology 7(1):R1
REVIEW ARTICLES:
- Groom HCT, Bishop KN The tale of xenotropic murine leukemia virus-related virus 2012 J Gen Virol93(Pt 5):915-24
- Groom HCT, Anderson EC, Lever AM Rev: beyond nuclear export2009 J Gen Virol 90(Pt 6):1303-18
