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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Dr Olivier Restif

Dr Olivier Restif

Senior Lecturer in Epidemiology

Fellow of Robinson College

Olivier Restif is accepting applications for PhD students.

Department of Veterinary Medicine
Madingley Road

Cambridge CB3 0ES

Termination details:

I use mathematical models combined with experimental and field-based studies to investigate the dynamics of infectious diseases at all scales, from cells to ecosystems. My research falls into four main subjects:
- Within-host dynamics of bacterial infections.
- Evolutionary ecology of immune defences.
- Microcosm studies of host-pathogen population dynamics.
- Model-Guided Fieldwork for Wildlife Infectious Diseases.

Departments and Institutes

Veterinary Medicine:
Research Fellow

Research Interests

I use mathematical models combined with experimental and field-based studies to investigate the dynamics of infectious diseases at all scales, from cells to ecosystems. My research falls into three main areas:
1. Within-host dynamics of bacterial infections.
2. Quantitative methods for multi-drug resistance.
3. One Health approach to emerging zoonotic diseases.
 

See here for more details on my research.

Keywords

  • Bayesian Methods
  • Ecology
  • Host-Pathogen Interaction
  • Antimicrobial resistance
  • Africa
  • Simulation
  • Epidemiology

Topics

  • Henipavirus
  • Rabies
  • Salmonellosis
  • Emerging viral diseases
  • Ebola
  • Zoonoses

Equipment

  • Statistical Methods
  • Mathematical modelling
  • Computational modelling

Key Publications

Vlazaki M, Huber J and Restif O (2019)  Integrating mathematical models with experimental data to investigate the within-host dynamics of bacterial infections. Pathogens and Disease 77:fta001.https://doi.org/10.1093/femspd/ftaa001

Glennon EE, Becker DJ, Peel AJ, Garnier R, Suu-Ire RD, Gibson L, Hayman DTS, Wood JLN, Cunningham AA, Plowright RK and Restif O (2019) What is stirring in the reservoir? Modelling mechanisms of henipavirus circulation in fruit bat hosts. Philosophical Transactions of the Royal Society B: Biological Sciences 374:20190021. http://dx.doi.org/10.1098/rstb.2019.0021

Vlazaki M, Rossi O, Price DJ, McLean C, Grant AJ, Mastroeni P, Restif O. (2020) A data-based mathematical modelling study to quantify the effects of ciprofloxacin and ampicillin on the within-host dynamics of Salmonella enterica during treatment and relapse. Journal of The Royal Society Interface 17:2020.0299. https://doi.org/10.1098/rsif.2020.0299

Glennon EE, Jephcott F, Restif O, Wood JLN (2019) Estimating undetected Ebola spillovers. PLoS Neglected Tropical Diseases 13:e0007428. https://doi.org/10.1371/journal.pntd.0007428

Price DJ, Breuzé A, Dybowski R, Mastroeni P, Restif O (2017) An efficient moments-based inference method for within-host bacterial infection dynamics. PLOS Computational Biology 13(11): e1005841. https://doi.org/10.1371/journal.pcbi.1005841

Plowright RK, Peel AJ, Streicker DG, Gilbert A , McCallum H, Wood JLN, Baker ML, Restif O (2016). Transmission or within-host dynamics driving pulses of zoonotic viruses in reservoir-host populations. PLoS Neglected Tropical Diseases 10: e0004796. doi:10.1371/journal.pntd.0004796

Peel AJ, Baker, KS, Hayman DTS, Broder CC, Cunningham AA, Fooks AR, Garnier R, Wood JLN, Restif O (2018) Support for viral persistence in bats from age-specific serology and models of maternal immunity. Scientific Reports 8, 3859, doi:10.1038/s41598-018-22236-6

Coward et al (2014) The Effects of Vaccination and Immunity on Bacterial Infection Dynamics In Vivo. PLoS Pathogens, 10(9): e1004359, Full text 

Peel AJ et al (2014) The effect of seasonal birth pulses on pathogen persistence in wild mammal populations. Proc R Soc B, 281:20132962. Full text 

Restif O et al. (2012) Model‐guided fieldwork: practical guidelines for multidisciplinary research on wildlife ecological and epidemiological dynamics. Ecology Letters 15:1083. Full text