Professor Ian Goodfellow

Professor of Virology, Division of VirologyDeputy Head of Department (Research)Virology of calicivirus

Characterisation of the novel mechanism of calicivirus protein synthesis
Current work focuses on the proteomic analysis of the components of the calicivirus translation initiation complex, structural analysis of the roles of other translation initiation factors in calicivirus translation, as well as the identification of inhibitors of this novel translation mechanism as potential anti-viral therapeutics.

Characterisation of calicivirus replication complex formation
This project aims to characterise the viral and cellular proteins (and processes) involved in replication complex formation using a combination of imaging, molecular and biochemical approaches.

Identification and characterisation of RNA-protein interactions required for calicivirus replication
This project aims to identify the cis-acting functional RNA structures within the viral genome as well as the viral and host cell proteins which interact with these structures, and then to subsequently determine the role of these interactions in the norovirus life cycle. This will not only give us a greater insight into how these viruses replicate but will also lead to the identification of method for rationale attenuation of noroviruses.

Funding for our research comes from numerous sources including the BBSRC, Marie Curie, MRC and Wellcome Trust.

Group Members:
Armando Airas, Sarah Caddy, Constantina Christodolou, Edward Emmott, Yasmin Goodfellow, Nora McFadden, Lucy Thorne, Surrender Vashist