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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Professor Ian Goodfellow

Professor Ian Goodfellow

Department of Pathology

Virus-host interactions, with particular emphasis on noroviruses.


Biography:

Professor of Virology, Division of Virology

Deputy Head of Department (Research)

Virology of calicivirus

Characterisation of the novel mechanism of calicivirus protein synthesis
Current work focuses on the proteomic analysis of the components of the calicivirus translation initiation complex, structural analysis of the roles of other translation initiation factors in calicivirus translation, as well as the identification of inhibitors of this novel translation mechanism as potential anti-viral therapeutics.

Characterisation of calicivirus replication complex formation
This project aims to characterise the viral and cellular proteins (and processes) involved in replication complex formation using a combination of imaging, molecular and biochemical approaches.

Identification and characterisation of RNA-protein interactions required for calicivirus replication
This project aims to identify the cis-acting functional RNA structures within the viral genome as well as the viral and host cell proteins which interact with these structures, and then to subsequently determine the role of these interactions in the norovirus life cycle. This will not only give us a greater insight into how these viruses replicate but will also lead to the identification of method for rationale attenuation of noroviruses.

Funding for our research comes from numerous sources including the BBSRC, Marie Curie, MRC and Wellcome Trust.

Group Members:
Armando Airas, Sarah Caddy, Constantina Christodolou, Edward Emmott, Yasmin Goodfellow, Nora McFadden, Lucy Thorne, Surrender Vashist

Departments and Institutes

Pathology:

Keywords

  • Genomics
  • Immune Evasion
  • Viral pathogenicity
  • Molecular Biology
  • Macrophages
  • Host-Pathogen Interaction
  • Vaccine development
  • Innate Immunity
  • Infection
  • Virulence
  • Pathogenesis
  • Sequencing
  • Gene Expression
  • Gene Regulation

Topics

  • Norovirus
  • Gastroenteritis
  • RNA virus

Key Publications

  1. Vashist S, Urena L, Chaudhry Y, Goodfellow I. Identification of RNA-protein interaction networks involved in the norovirus life cycle. J Virol. 2012 Aug 29. PubMed PMID: 22933270.
  2. Thorne L, Bailey D, Goodfellow I. High-resolution functional profiling of the norovirus genome. J Virol. 2012 Nov;86(21):11441-56. PubMed PMID: 22915807.
  3. Subba-Reddy CV, Yunus MA, Goodfellow IG, Kao CC. Norovirus RNA Synthesis Is Modulated by an Interaction between the Viral RNA-Dependent RNA Polymerase and the Major Capsid Protein, VP1. J Virol. 2012 Sep;86(18):10138-49. PubMed Central PMCID: PMC3446604.
  4. Arias A, Ureña L, Thorne L, Yunus MA, Goodfellow I. Reverse genetics mediated recovery of infectious murine norovirus. J Vis Exp. 2012 Jun 24;(64). pii: 4145. PubMed PMID: 22760450.