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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge
 

Research

Viruses that seek to exploit the rich environment inside host cells face a logistical dilemma: How can they subvert host membrane trafficking to ensure progeny virions efficiently exit infected cells? I study how viruses modify the composition and architecture of infected cell membranes, with a special emphasis on how viruses that acquire double membrane envelopes within cells are trafficked to and fuse with the plasma membrane.

Publications

Key publications: 
    1. B.G. Butt, D.J. Owen, C.M. Jeffries, L. Ivanova, C.H. Hill, J.W. Houghton, M.F. Ahmed, R. Antrobus, D.I. Svergun, J.J. Welch, C.M. Crump, S.C. Graham (2020) Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex. eLife, 9: e53789 [doi: 10.7554/eLife.53789]

    2. T.K. Soh*, C.T.R. Davies*, J. Muenzner*, L.M. Hunter, H.G. Barrow, V. Connor, C.R. Bouton, C. Smith, E. Emmott, R. Antrobus, S.C. Graham^, M.P. Weekes^, C.M. Crump^ (2020) Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation. Cell Reports, 33: 108235 [doi: 10.1016/j.celrep.2020.108235]

    3. C. Conceicao*, N. Thakur*, S. Human, J.T. Kelly, L. Logan, D. Bialy, S. Bhat, P. Stevenson-Leggett, A.K. Zagrajek, P. Hollinghurst, M. Varga, C. Tsirigoti, M. Tully, C. Chiu, K. Moffat, A.P. Silesian, J.A. Hammond, H.J. Maier, E. Bickerton, H. Shelton, I. Dietrich, S.C. Graham, D. Bailey (2020) The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins. PLoS Biology 18: e3001016 [doi: 10.1371/journal.pbio.3001016]

    4. C. Gao, M.A. Pallett, T.I. Croll, G.L. Smith, S.C. Graham (2019) Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55. Journal of Biological Chemistry, 294: 6416–6429 [doi: 10.1074/jbc.RA118.006561]

    5. J.M. Alves, M. Carneiro, J.Y. Cheng, A. Lemos de Matos, M.M. Rahman, L. Loog, P.F. Campos, N. Wales, A. Eriksson, A. Manica, T. Strive, S.C. Graham, S. Afonso, D.J. Bell, L. Belmont, J.P. Day, S.J. Fuller, S. Marchandeau, W.J. Palmer, G. Queney, A.K. Surridge, F.G. Vieira, G. McFadden, R. Nielsen, M.T.P. Gilbert, P.J. Esteves, N. Ferrand, F.M. Jiggins (2019) Parallel adaptation of rabbit populations to myxoma virus. Science, 363: 1319–1326 [doi: 10.1126/science.aau7285]

    6. A. Albecka, D.J. Owen, L. Ivanova, J. Brun, R. Liman, L. Davies, M.F. Ahmed, S. Colaco, M. Hollinshead, S.C. Graham^ and C.M. Crump^ (2017) Dual function of the pUL7-pUL51 tegument protein complex in HSV-1 infection. Journal of Virology, 81: e02196-16 [doi: 10.1128/JVI.02196-16]

    7. J. Muenzner, L.M. Traub, B.T. Kelly^, S.C. Graham^ (2017) Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin. Traffic, 18: 44–57 [doi: 10.1111/tra.12457]

     (^Joint corresponding authors)

    Molecular mechanisms of membrane trafficking in virus infection
    Dr Stephen  Graham
    Takes PhD students
    Available for consultancy

    Affiliations

    Classifications: 
    Departments and institutes: 
    Person keywords: 
    Virion assembly
    Immune Evasion
    Molecular Biology
    Host-Pathogen Interaction
    Virology
    Pathogen Evolution
    Structural Biology