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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge


Pietro Mastroeni

Pietro Mastroeni

Reader in Infection and Immunity



1990. Doctor of Medicine and Surgery at the University of Messina, Italy.

1991-94. Doctor of Philosophy (PhD), Department of Pathology and Darwin College, University of Cambridge.

2017. Doctor of Science (ScD), University of Cambridge.


Professional history.

1992-96. Ricercatore Universitario in Malattie Infettive (tenured Lectureship in Infectious Diseases), University of Messina, Italy.

1997. Research Associate at the University of Newcastle, Department of Microbiology, The Medical School, Newcastle upon Tyne, UK.

1997-1999. Research Fellow, Department of Biochemistry, Imperial College of Science, Technology and Medicine, University of London, UK.

1999-2004. University Lecturer in Microbiology, Department of Veterinary Medicine, University of Cambridge.

2004-2008. University Senior Lecturer in Microbiology, Department of Veterinary Medicine, University of Cambridge.

Departments and Institutes

Veterinary Medicine:

Research Interests

Our past research has defined the role of cytokine networks, antibodies, phagocytes, B-cells and T-cells in host resistance to bacterial infections.

Recent research is focused on pathogen behaviour (e.g. location, growth, spread in the body, gene regulation) in vivo at the single cell level in relation to immunity, vaccines and antibiotics. This work is delving into the bases of post-therapy microbial persistence and vaccine efficacy/failures. We use interdisciplinary research approaches that integrate information acquired at different levels spanning from individual cells to global systems. This work opens the field to high-impact research on new prevention measures and medical treatments. 

We are also delving into the interactions between the host and the bacterial genome. This work is allowing the selection of new vaccine candidates that would be safer in the developing world where immune-compromise poses challenges to vaccination.  


  • Immunology
  • Macrophages
  • Host-Pathogen Interaction
  • Vaccine development
  • Pathogenesis
  • Innate Immunity
  • Infection
  • Transcriptomics
  • T-Cell
  • Inflammation
  • Vaccine
  • Bacteriology
  • Immune Evasion
  • Antibody
  • Gene Regulation


  • Salmonellosis
  • Zoonoses
  • Salmonella
  • Typhoid Fever


  • Confocal microscopy
  • Cell culture

Key Publications

Key publications since year 2000 (older first).

Igh-6-/- mice (B-cell deficient) fail to mount acquired resistance to oral challenge with virulent Salmonella enterica serovar Typhimurium and show impaired Th1 T-cell responses to Salmonella antigens. Pietro Mastroeni, C. Simmons, R. Fowler, C. Hormaeche, G. Dougan. Infect. Immun. 2000; 68: 46-53.

Salmonella pathogenicity Island 2 (SPI-2)-dependent evasion of the phagocyte NADPH oxidase. A. Vazquez-Torres, Y. Xu, D. Holden, S. Lucia, M. Dinauer, P. Mastroeni, F. Fang. Science 2000; 287:1655-1658.

Streptococcal acid glycoprotein (SAGP) is the Streptococcus pyogenes equivalent of arginine deiminase: characterization of an isogenic mutant Manfredo strain of group A Streptococcus lacking ability to make SAGP. B. Degnan, M. Fontaine, A. Doberainer, Pietro Mastroeni, G. Dougan, M. Kehoe, J. Goodacre. Infect. Immun. 2000; 68: 2441-2448.

Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effect on microbial killing by activated peritoneal macrophages in vitro. A. Vazquez-Torrez, J. Jones-Carson, Pietro Mastroeni, H. Ischiropoulos, C. Nathan, F. Fang. J. Exp. Med. 2000; 192: 227-236.

Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects of microbial proliferation and host survival in vivo. Pietro Mastroeni, A. Vazquez-Torrez, F. Fang, Y. Xu, S. Khan, C. Hormaeche, G. Dougan. J. Exp. Med. 2000; 192: 237-247.

Early responses to Salmonella typhimurium infection in mice occur at focal lesions in infected organs. S. Khan, P. Strijbos, P. Everest, D. Moss, R. Stratford, Pietro Mastroeni, J. Allen, S. Servos, I. Charles, G. Dougan, D. Maskell. Microb. Pathog. 2001; 30: 29-38.

Role of antibody to lipopolysaccharide in protection against low and high-virulence strains of Francisella tularensis. M. Fulop, Pietro Mastroeni, M. Green, R. Titball. Vaccine 2001; 19: 4465-4472.

Increased susceptibility of C1q-deficient mice to Salmonella infection. J. Warren, Pietro Mastroeni, G. Dougan, J. Cohen, M. Walport, M. Botto. Infect. Immun. 2002; 70: 551-557.

Development of Salmonella typhi and S. typhimurium strains derivatives harbouring deletions in aromatic biosynthesis and Salmonella pathogenicity island-2 (SPI-2) genes as vaccines and vaccine vectors. S. Khan, R. Stratford, T. Wu, N. McKelvie, T. Bellaby, Z. Hindle, K. Sinha, S. Eltze, Pietro Mastroeni, D. Pickard, G. Dougan, S. Chatfield. F. Brennan. Vaccine 2003; 21: 538-548.

Dynamics of bacterial growth and distribution within the liver during Salmonella infection M. Sheppard, C. Webb, F. Heath, V. Mallows, D. Maskell, Pietro Mastroeni. Cell. Microbiol. 2003; 5: 593-600.

Role of ICAM-1 in the pathology of Salmonella infections in mice. S. Clare, Pietro Mastroeni, G. Dougan. Infect. Immun. 2003; 71: 5881-5891.

Characterisation and development of T-cell immune responses in B-cell deficient (Igh-6-/-) mice in Salmonella typhimurium infection. S. Ugrinovic, N. Menager, N. Goh, Pietro Mastroeni. Infect. Immun. 2003; 71: 6808-6819.

Rapid expression of chemokines and pro-inflammatory cytokines in newly hatched chickens infected with Salmonella enterica serovar Typhimurium. G. Withanage, P. Kaiser, P. Wigley, C. Powers, Pietro Mastroeni, H. Brooks, D. Maskell, I. McConnell. Infect. Immun. 2004; 72: 2152-2159.

A clinical, microbiological and pathological study of intestinal perforation associated with typhoid fever. N. Chanh, P. Everest, T. Khoa, D. House, S. Murch C. Parry, P. Connerton, P. van Bay, T. Diep, Pietro Mastroeni, N. White, T. Hien, V. Van Ho, G. Dougan, J. Farrar,J. Wain. J. Infect. Dis. 2004; 39: 61-67.

Attenuated Salmonella typhimurium htrA mutants are invasive in mice and macrophages deficient in NADPH oxidase. M. Mutunga, S. Graham, R. Demarco de Hormaeche, J. Musson, J. Robinson, Pietro Mastroeni, A. Khan, C. Hormaeche. Vaccine 2004; 22: 4124-4131.

DNA-Salmonella prime-boost vaccination biases towards T helper 1 responses and enhances protection against Leishmania major infection in mice. U. Lange, Pietro Mastroeni, J. Blackwell, C. Stober. Infect. Immun. 2004; 72: 4924-4928.

Salmonella infection down-regulates cell surface MHC class II expression. E. Mitchell, Pietro Mastroeni, A. Kelly, J. Trowsdale. Eur. J. Immunol. 2004; 34: 2559-2567.

Late stage disease modulation in NOD mice by Salmonella typhimurium. P. Zaccone, T. Raine, S. Sidobre, M. Kronenberg, Pietro Mastroeni, A. Cooke. Eur. J. Immunol. 2004; 34: 3246-3256.

Interactions of proteoliposomes from serogroup B N. meningitidis with bone marrow-derived dendritic cells and macrophages: adjuvant effects and antigen delivery. T. Rodriguez, O. Perez, G. Bracho, S. Ugrinovic, Pietro Mastroeni. Vaccine 2005; 23: 1312-1321.

Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity. J. White, Pietro Mastroeni, J. Popoff, C. Evans, J. Blackwell. J. Leuk. Biol. 2005; 77: 311-320.

A Salmonella typhimurium effector protein SifA is modified by host cell prenylation and S-acylation machinery. A. Reinicke, J. Hutchinson, A. Magee, Pietro Mastroeni, J. Trowsdale, A. Kelly. J. Biol. Chem. 2005; 280: 14620-14627.

Oxidative and nitrosative responses of chicken macrophage cell line MQ-NCSU to experimental Salmonella infection in vitro. G. Withanage, Pietro Mastroeni, H. Brooks, I. McConnell, D. Maskell. British Poultry Science 2005; 46: 261-267.

Activation of murine dendritic cells and macrophages induced by Salmonella enterica serovar Typhimurium. R. Kalupahana, Pietro Mastroeni, D. Maskell, B. Blacklaws. Immunology 2005; 115: 462-472.

Cytokine and chemokine responses associated with clearance of a primary Salmonella enterica serovar Typhimurium infection in the chicken and in protective immunity to rechallenge. G. Withanage, P. Wigley, P. Kaiser, Pietro Mastroeni, H. Brooks, C. Powers, R. Beal, P. Barrow, D. Maskell, I. McConnell. Infect. Immun. 2005; 73: 5173-5182.

Evaluation of a novel Vi conjugate vaccine in a murine model of salmonellosis. C. Hale, F. Bowe, D. Pickard, S. Clare, J. Haeuw, U. Powers, N. Menager, Pietro Mastroeni, G. Dougan. Vaccine 2006; 24: 4312-4320.

Effect of immune serum and role of individual Fcg receptors on the intracellular distribution and survival of S. enterica serovar Typhimurium in mononuclear cells. H. Uppington, N. Menager, P. Boross, J. Wood, M. Sheppard, S. Verbeek, Pietro Mastroeni. Immunology 2006; 119: 147-158.

S. typhimurium infection in NOD mice generates lasting populations of immunomodulatory DCs able to prevent Type 1 Diabetes and to influence autoreactive T cell trafficking. T. Rayne, P. Zaccone, Pietro Mastroeni, A. Cooke. J. Immunol. 2006; 177: 2224-2233.

Intracellular demography and the dynamics of Salmonella typhimurium. S. Brown, S. Cornell, M. Sheppard, A. Grant, D. Maskell, B. Grenfell, Pietro Mastroeni.. PLoS Biol. 2006; 4: 2091-2098.

Fcgamma receptors are crucial for the expression of acquired resistance to virulent S. enterica serovar typhimurium in vivo but are not required for the induction of humoral or T cell mediated immunity. N. Menager, G. Foster,S. Ugrinovic, H. Uppington, S. Verbeek, Pietro Mastroeni. Immunology 2007; 120: 424-432.

Live attenuated Salmonella as a vector for oral cytokine gene therapy in melanoma. C. Agorio,  F. Schreiber,  M. Sheppard, Pietro Mastroeni, M. Fernandez, M. Martinez, J. Chabalgoity. J. Gene Med. 2007; 9: 416-423.

The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro. J. Beech, D. Wheeler, J. Reckless, A. Grant, J. Price, Pietro Mastroeni, D. Grainger, D. Menon. J. Neuroimmunol. 2007; 184: 198-208.

LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar Typhimurium. M. Karavolos, D. Bulmer, K. Winzer, M. Wilson, P. Mastroeni, P. Williams, A. Khan. J Bacteriol. 2008; 190: 769-771.

Salmonella infection of afferent lymph dendritic cells. S. Chan, Pietro Mastroeni, I. McConnell, B. Blacklaws.  J. Leuk. Biol. 2008; 83: 272-279.

Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice. A. Grant, M. Sheppard, R. Deardon, S. Brown, G. Foster, C. Bryant, D. Maskell, Pietro Mastroeni. Immunology 2008; 125:28-37.

Modeling within-host spatiotemporal dynamics of invasive bacterial disease. A. Grant, O. Restif, M. Sheppard, T. McKinley, D. Maskell, Pietro Mastroeni. PLoS Biol. 2008; 6: e74.

An attenuated S. enterica strain can increase the growth of a virulent strain via production of IL-10 requiring TLR4 signalling via TRIF and MyD88. G. Foster, T. Barr, A. Grant, C. Bryant, A. MacDonald, D. Gray, M. Yamamoto, S. Akira, D. Maskell, Pietro Mastroeni. Immunology 2008; 124: 469-479.

B-cell intrinsic MyD88 signals drive IFN-γ production from T cells and control switching to IgG2c. T. Barr, S. Brown, Pietro Mastroeni, D. Gray. J. Immunol., 2009; 183: 1005-1012.

Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, transmission and disease in immunocompromised hosts. T. Lawley, S. Clare, A. Walker, D. Goulding, R. Stabler, N. Croucher, Pietro Mastroeni, P. Scott, C. Raisen, L. Mottram, N. Fairweather, B. Wren, J. Parkhill, G. Dougan. Infect. Immun. 2009; 77: 3661-3669.

Multiple redundant stress resistance mechanisms are induced in Salmonella enterica serovar Typhimurium in response to alteration of the intracellular environment via TLR4 signalling. J. Wright, S. Tötemeyer, I. Hautefort, C. Appia-Ayme, M. Alston, V. Danino, G. Paterson, Pietro Mastroeni, N. Ménager, M. Rolfe, A.Thompson, S. Ugrinovic, L. Sait, T. Humprey, H. Northen, S. Peters, D. Maskell, J. Hinton, C. Bryant. Microbiology. 2009; 155: 2919-2929.

Bacterial growth rate and host factors as determinants of intracellular bacterial distributions in systemic Salmonella enterica infections. A. Grant, G. Foster, T. McKinley, S. Brown, S. Clare, M. Sheppard, D. Maskell,Pietro Mastroeni. Infect. Immun. 2009; 77: 5608-5611.

LuxS-based quorum sensing does not affect the ability of Salmonella to express the SPI-1 Type 3 secretion system, induce membrane ruffles or invade epithelial cells. C. Perrett, I. Martinez-Argudo, M. Karavolos, H. Spencer, D. Bulmer, Pietro Mastroeni, K. Winzer,E. McGhie, V. Koronakis, P. Williams, A. Khan, M. Jepson. J. Bacteriol. 2009; 191: 7253-7259.

Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar Typhimurium infection, but not for the initiation of bacterial clearance. S. Talbot, S. Tötemeyer, M. Yamamoto, S. Akira, K. Hughes, D. Gray, T. Barr, Pietro Mastroeni, D. Maskell, C. Bryant. Immunology. 2009; 128: 472-483.

Salmonella enterica serovar Typhimurium trxA mutants are protective against virulent challenge but induce less inflammation than the live-attenuated vaccine strain SL3261. S. Peters, G. Paterson, E. Bandularatne, H. Northen, S. Pleasance, C. Willers, J. Wang, A. Foote, F. Constantino-Casas, T. Scase, B. Blacklaws, C. Bryant, Pietro Mastroeni, I. Charles, D. Maskell. Infect. Immun. 2010; 78: 326-336.

Importance of antibody and complement for oxidative burst and blood cell killing of invasive nontyphoidal Salmonella in Africans. E. Gondwe, M. Molyneux, M. Drayson, S. Graham, Pietro Mastroeni, C.  MacLennan. PNAS. 2010; 107: 3070-3075.

Salmonella enterica serovar Typhimurium mutants completely lacking the F0F1 ATPase are novel live attenuated vaccine strains. H. Northen, G. Paterson, F. Constantino-Casas, C. Bryant, S. Clare, Pietro Mastroeni, S. Peters, D. Maskell. Vaccine. 2010; 28: 940-949.

TLR and BCR signals to B cells differentially programme primary and memory Th1 responses to Salmonella enterica. T. Barr, S. Brown, Pietro Mastroeni*, D. Gray*.  *Joint senior authors. J. Immunol., 2010; 185: 2783-2789.

Copper homeostasis in Salmonella is atypical: contribution to survival inside macrophages. D. Osman, K. Waldron, H. Denton, C. Taylor, A. Grant, Pietro Mastroeni, N. Robinson J. Cavet. J. Biol. Chem. 2010; 285: 25259-25268.

Anaesthetic impairment of immune function is mediated via GABAA receptors. D. Wheeler, A. Thompson, F. Corletto, J. Reckless, J. Loke, N. Lapaque, A. Grant, Pietro Mastroeni, D. Grainger, C. Padgett, J. O’Brien, N. Miller, J. Trowsdale, S. Lummis, D. Menon, J. Beech. PloS One. 2011; 6(2):e17152.

Enhanced virulence of Salmonella enterica serovar Typhimurium after passage through mice. Pietro Mastroeni, F. Morgan, T. McKinley, G. Foster, E. Shawcroft, S. Clare, D. Maskell, A. Grant., Infect. Immun. 2011; 79:636-643.

Human IgG isotypes and activating Fcgamma receptors in the interaction of S. Typhimurium with phagocytic cells. Y. Goh, O. Restif, T. McKinley, K. Armour, A. Grant, M. Clark, Pietro Mastroeni. Immunology. 2011; 133:74-83.

In vivo regulation of the antigen Vi in Salmonella and induction of immune responses with an in vivo inducible promoter. C. Janis, A. Grant, T. McKinley, F. Morgan, V. John, J. Houghton, R. Kingseley, G. Dougan, Pietro Mastroeni. Infect. Immun. Spotlight Article, 2011; 79: 2481-2488.

PD-L1 blockade overrides Salmonella Typhimurium-mediated diabetes prevention in NOD mice: No role for Tregs. S. Newland, J. Phillips, P. Mastroeni, M. Azuma, P. Zaccone, A. Cooke. Eur. J. Immunol. 2011 Jul 26. doi: 10.1002/eji.201141544.

A Salmonella Typhimurium-Typhi genomic chimera: a model to study Vi polysaccharide capsule function in vivo. A. Jansen, L. Hall, S. Clare, D. Goulding, K. Holt, A. Grant, Pietro Mastroeni, G. Dougan, R. Kingsley. Plos Pathogens, 2011; 7:e1002131..

The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella. D. Bulmer, L. Kharraz, A. Grant, P. Dean, F. Morgan, M. Karavolos, A. Doble, E. McGhie, V. Koronakis, R. Daniel, Pietro Mastroeni, A. Khan. PLoS Pathog. 2012 Jan;8(1):e1002500.

 Dynamics of Salmonella infection of macrophages at the single cell level. J. Gog, A. Murcia, N. Osterman, O. Restif, T. McKinley, M. Sheppard, S. Achouri, B. Wei, Pietro Mastroeni, J. Wood, D. Maskell, P. Cicuta, C. Bryant. J. R. Soc. Interface 2012; 9: 2696-2707.

 Quantification of the effects of antibodies on the extra- and intracellular dynamics of Salmonella enterica. O. Restif, Y. Goh, M. Palayret, A. Grant, T. McKinley, J. Gog, Pietro Mastroeni. J. R. Soc. Interface. 2013; 10: 20120866

 Attenuated Salmonella Typhimurium lacking the pathogenicity island-2 type 3 secretion system grow to high bacterial numbers inside phagocytes in mice. A. Grant, F. Morgan, T. McKinley, G. Foster, D. Maskell, Pietro Mastroeni. PLoS Pathog. 2012; 8: e1003070

  Enhanced susceptibility to Citrobacter rodentium infection in miR-155- deficient mice. S. Clare, V. John, A. Walker, J. Hill, C. Abreu-Goodger, C. Hale, D. Goulding, T. Lawley, Pietro Mastroeni, G. Frankel, A. Enright, E. Vigorito, G. Dougan. Infect. Immun. 2013; 81: 723-732.

Nested sampling for Bayesian model comparison in the context of Salmonella disease dynamics. R. Dybowski, T. McKinley, Pietro Mastroeni, O. Restif. PLoS one 2013; 8(12):e82317.

The effects of vaccination and immunity on bacterial infection dynamics in vivo. C. Coward, O. Restif, R. Dybowski, A. Grant, D. Maskell, Pietro Mastroeni. PLoS Pathog. 2014; 10(9):e1004359. .

Design of glycoconjugate vaccines against invasive African S. Typhimurium. S. Rondini, F. Micoli, L. Lanzilao, M. Gavini, Pietro Mastroeni, C. Brandt, A. Saul, C. MacLennan.  Infect. Immun. 2015; 83:996-1007.

 Monoclonal antibodies of diverse isotype induced by an O-antigen glycoconjugate vaccine mediate in vitro and in vivo killing of African invasive nontyphoidal Salmonella. Y.S. Goh,S. Clare, F. Micoli, A. Saul, Pietro Mastroeni,Calman A. MacLennan. Infect. Immun. 2015; 83:3722-3731.

  TARM1 is a novel leukocyte receptor complex-encoded ITAM receptor that costimulates proinflammatory cytokine secretion by macrophages and neutrophils. V. Radjabova, Pietro Mastroeni, K. Skjodt, P. Zaccone, B. de Bono, J Goodall, E.  Chilvers, J. Juss, D. Jones, J. Trowsdale, A. Barrow. J.  Immunol. 2015; 195:3149-3159.

Single passage in mouse organs enhances the survival and spread of Salmonella enterica. R. Dybowski, O. Restif, D. Maskell, Pietro Mastroeni, A. Grant. Royal Society Interface 2015; 12: 20150702. doi: 10.1098/rsif.2015.0702.

 Genes required for the fitness of Salmonella enterica serovar Typhimurium during infection of immunodeficient gp91-/-phox mice". A. Grant, O. Oshota, R. Chaudhuri, M. Mayho, S. Peters, S. Clare, D. Maskell, Pietro Mastroeni. Infect. Immun. 2016; 84: 989-997.


 IgG subclasses targeting the flagella of Salmonella enterica serovar Typhimurium can mediate phagocytosis and bacterial killing. Y. S. Goh, K. Armour, M. Clark, A. Grant, Pietro Mastroeni. Journal of Vaccines and Vaccination, 2016; 7: pii:322.

 Genomic variations leading to alterations in cell morphology of Campylobacter spp. D. Esson, A. Mather, E. Scanlan, S. Gupta, S. de Vries, D. Bailey, S. Harris, T. McKinley, G. Méric, S. Berry, Pietro Mastroeni, S. Sheppard, G. Christie, N. Thomson, J. Parkhill, D. Maskell, A. Grant. Scientific Reports, 2016 Dec 2;6:38303. doi: 10.1038/srep38303.

 Plant lectins ConBr and CFL modulate expression of toll-like receptors besides pro-inflammatory cytokines and reduce the bacterial burden within macrophages infected with Salmonella enterica serovar Typhimurium. J. Batista, M. Ralph, P. Souza, M. Ramos, Pietro. Mastroeni, J. Lima-Filho. Phytomedicine, 2017;25:52-60.

 Effect of in vivo neutralisation of Tumor Necrosis Factor alpha on the efficacy of antibiotic treatment in systemic Salmonella enterica infections. O. Rossi, A. Grant, Pietro Mastroeni. Pathogen. Dis., 2017, doi: 10.1093/femspd/ftx002.

 Identification and characterisation of a protein involved in Campylobacter jejuni cell shape. D. Esson, S. Gupta, D. Bailey, P. Wigley, A. Wedley, A. Mather, G. Méric, Pietro Mastroeni, S. Sheppard, N. Thomson, J. Parkhill, D. Maskell, G. Christie, A.Grant. Microb. Pathogen., 2017,

 Inferring within-host bottleneck size: a Bayesian approach. R. Dybowski, O. Restif, D. Price, Pietro Mastroeni. Journal of Theoretical Biology, 2017, i 435:218-228. doi: 10.1016/j.jtbi.2017.09.011

 Cytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex. C. Viana, M. V. Ramos, J. Barreto Marinho Filho, L. Lotufo, I. Figueiredo, J. Soares de Oliveira, Pietro Mastroeni, J. Lima-filho, N. Alencar. Submitted to Naunyn-Schmiedeberg's Archives of Pharmacology, 2017 Jul 11. doi: 10.1007/s00210-017-1397-9.

 Within-host spatiotemporal dynamics of systemic Salmonella infection during and after antimicrobial treatment. O. Rossi, R. Dybowski, D. Maskell, A. Grant, O. Restif, P. Mastroeni. J. Antimicrob. Chemother.,

Transcriptome and proteome analysis of Salmonella enterica Serovar Typhimurium Infection of wild type C57BL/6 and immunodeficient gp91-/-phox mice. O. Oshota, M. Fookes, F. Schreiber, R.Chaudhuri, L. Yu, F. Morgan, S. Clare, J. Choudhary, N. Thomson, D. Maskell, Pietro Mastroeni, A. Grant. Plos One., 2017 Aug 10;12(8):e0181365. doi: 10.1371/journal.pone.0181365

An efficient moments-based inference method for within-host bacterial infection dynamics. D. Price, A. Breuze, P Mastroeni, R. Dybowski, O. Restif. PloS Computational Biology, 2017 13(11): e1005841.

 Expression of Siglec-E alters the phenotype of macrophages but does not affect LPS driven cytokine production or TLR4 endocytosis.  M. Nagala, E. McKenzie, H. Richards, R. Sharma, S. Thomson, Pietro Mastroeni. P. Crocker. Frontiers in Immunol., doi: 10.3389/fimmu.2017.01926. eCollection 2017

Recent Review articles

A dynamic view of the spread and intracellular distribution of Salmonella enterica. Pietro Mastroeni, A. Grant, O. Restif, D. Maskell. Nature Rev. Microbiol. 2009; 7: 73-80.

Immunity to salmonellosis. G. Dougan, V. John, Pietro Mastroeni. Immunological Reviews, 2011; 240: 196-210.

The spread of Salmonella in the body: systems based approaches to unravel host and pathogen determinants. Pietro Mastroeni, A. Grant. Expert Reviews in Molecular Medicine, 2011;13:e12.

Dynamics of spread of Salmonella enterica in the systemic compartment. Pietro Mastroeni, A. Grant. Microbes and Infection, 2013; 15:849-857.

 Immunology, epidemiology and mathematical modelling towards a better understanding of invasive non-typhoidal Salmonella disease and rational vaccination approaches. Pietro Mastroeni, O. Rossi. Expert Reviews of Vaccines, 2016, DOI:10.1080/14760584.2016.1189330.

 Immunological basis of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia. T. Nyirenda, W. Mandala, M. Gordon, Pietro Mastroeni. Microbes and Infection, doi: 10.1016/j.micinf.2017.11.014.