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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Dr Charlotte Houldcroft

Dr Charlotte  Houldcroft

Post-doctoral research associate

Guest lecturer


Research themes

Host-Pathogen Interactions:
Viral Pathogens:

Host-virus interactions (Epstein-Barr virus)

Cytomegalovirus in immune compromised hosts

Adenovirus molecular epidemiology

Ancient infectious disease

Departments and Institutes

Medicine:
Post-doctoral research associate

Keywords

  • Latency
  • Immune Evasion
  • Host-Pathogen Interaction
  • Virology
  • Infection
  • Genetics

Topics

  • Genomics
  • Cytomegalovirus
  • Herpesvirus
  • RNA virus
  • EBV
  • Cytomegalovirus Infection
  • Public Health

Key Publications

Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study. L Meredith, W Hamilton, B Warne, C Houldcroft, M Hosmillo, AS Jahun et al. Lancet Infectious Diseases, 2020.

Assessing anti-HCMV cell mediated immune responses in transplant recipients and healthy controls using a novel functional assay. CJ Houldcroft, SE Jackson, Lim, E Y, GX Sedikides, EBM Remmerswaal et al. Frontiers in Cellular and Infection Microbiology, 2020.

Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination. J Cudini, S Roy, CJ Houldcroft, JM Bryant, DP Depledge, H Tutill, P Veys et al. Proceedings of the National Academy of Sciences, 2019.

Identification of novel adenovirus genotype 90 in children from Bangladesh. CJ Houldcroft, MA Beale, MA Sayeed, F Qadri, G Dougan, A Mutreja. Microbial Genomics, 2018.

Inferring the hominin origin of herpes simplex virus 2 from fossil, epidemiological and phylogenetic data. Underdown SJ, Kumar K & Houldcroft CJ. Virus Evolution, 2017. doi: 10.1093/ve/vex026

Clinical and biological insights from viral genome sequencing. Houldcroft CJ, Beale M & Breuer J. Nature Reviews Microbiology, 2017. doi: 10.1038/nrmicro.2016.182

Severe Epstein–Barr virus infection in primary immunodeficiency and the normal host. Worth AJJ, Houldcroft CJ and Booth C. British Journal of Haematology, 2016. doi: 10.1111/bjh.14339

Detection of Low Frequency Multi-Drug Resistance and Novel Putative Maribavir Resistance in Immunocompromised Pediatric Patients with Cytomegalovirus. Houldcroft CJ et al. Frontiers in Microbiology, 2016. doi: 10.3389/fmicb.2016.01317

Neanderthal Genomics Suggests a Pleistocene Time Frame for the First Epidemiologic Transition. Houldcroft CJ & Underdown S. American Journal of Physical Anthropology, 2016. doi: 10.1002/ajpa.22985

Host genetics of Epstein–Barr virus infection, latency and disease. Houldcroft CJ & Kellam P. Reviews in Medical Virology, 2015. doi: 10.1002/rmv.1816

Host Genetic Variants and Gene Expression Patterns Associated with Epstein-Barr Virus Copy Number in Lymphoblastoid Cell Lines. Houldcroft CJ et al. PLoS ONE, 2014. doi: 10.1371/journal.pone.0108384

Disease-associated XMRV sequences are consistent with laboratory contamination. Hué S, Gray ER, Gall A, Katzourakis A, Tan CP, Houldcroft CJ et al. Retrovirology, 2010. doi: 10.1186/1742-4690-7-111

Other Publications

Rabid about whole lyssa genomes. E Archer, CJ Houldcroft
Nature Reviews Microbiology, 316 2014

Sequencing drug-resistant cytomegalovirus in pediatric patients: toward personalized medicine. C Houldcroft
Future Virology, doi:10.2217/fvl.15.58 2015


Tales from the crypt and coral reef: the successes and challenges of identifying new herpesviruses using metagenomics. CJ Houldcroft, J Breuer
Frontiers in Microbiology 6, 188

Migrating microbes: inferring ancient human migrations from pathogen genomes. Houldcroft CJ, Ramond JB, Rifkin R & Underdown SJ. Annals of Human Biology, 2017. doi: 10.1080/03014460.2017.1325515