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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at The University of Cambridge

Studying at Cambridge

 

Professor David Dunne

Professor David Dunne

Epidemiology and Immunology of Schistosomiasis and other Human Parasitic Diseases.


Research Interests

Multidisciplinary studies on immunity to and the immunomorbidity of human schistosomiasis in disease endemic areas of sub-Saharan Africa. Interactions between co-infecting parasites in man, including the exacerbating effects of co-exposure to schistosomiasis and malaria on hepatic disease in school-aged children. Human IgE and IgE-mediated effector mechanisms in African populations and association with between immunity and susceptibility to schistosomiasis, and hookworm, and allergic diseases. This research is carried out in partnership with long-term collaborating scientists in Kenya, Uganda and Mali.

Topics

  • Schistosomiasis

Key Publications

  • Pinot de Moira A, Jones FM, Wilson S, Tukahebwa E, Fitzsimmons CM, Mwatha JK, Bethony JM, Kabatereine NB, Dunne DW. (2013). Childhood schistosome and hookworm co-infections: effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection. Infect Immun. 81:23-32.
  • Wilson S, Jones FM, Fofana HKM, Loundré A, Kimani G, Mwatha JK, Sacko M, Vennervald BJ, Dunne DW. (2013) Rapidly boosted plasma IL-5 induced by treatment of human schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils. PLoS Neglected Tropical Diseases. PNTD-D-12-01323R2
  • Fitzsimmons CM, Jones FM, Pinot de Moira A, Protasio AV, Khalife J, Dickinson HA, Tukahebwa EM, Dunne DW. (2012). Progressive cross-reactivity in IgE responses: an explanation for the slow development of immunity to human schistosomiasis Infect Immun. 80:4264-70
  • Fitzsimmons CM, Jones FM, Stearn A, Chalmers IW, Hoffmann KF, Wawrzyniak J, Wilson S, Kabatereine NB, Dunne DW. (2012) The Schistosoma mansoni Tegumental-Allergen-Like (TAL) Protein Family: Influence of Developmental Expression on Human IgE Responses. PLoS Negl Trop Dis 6(4):e1593.
  • Dunne, DW., Vennervald, BJ., Booth, M., Joseph, S., Fitzsimmons, CM., Cahen, P., Sturrock, RF., Ouma, JH., Mwatha, JK., Kimani, G., Kariuki, HC., Kazibwe, F., Tukahebwa, E., Kabatereine, NB. (2006) Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda.Transactions of the Royal Society for Tropical Medicine & Hygiene 100:216-23