We are searching for genes in the human genome that carry sequence
variants, which are involved in resistance to infection and predispose
to infectious diseases. Discovery of such genes can open new biological
pathways and suggest new targets for intervention. We use methods of
human genetics, including genome-wide association studies (GWAS) and
exome sequencing, in vitro models of infection and methods of molecular
biology to understand underlying biological mechanisms protecting from
infection.
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R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA and The Wellcome Trust
Case Control Consortium (2007), “Localisation of type 1
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