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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge
 

Research

We are searching for genes in the human genome that carry sequence
variants, which are involved in resistance to infection and predispose
to infectious diseases. Discovery of such genes can open new biological
pathways and suggest new targets for intervention. We use methods of
human genetics, including genome-wide association studies (GWAS) and
exome sequencing, in vitro models of infection and methods of molecular
biology to understand underlying biological mechanisms protecting from
infection.

Publications

Key publications: 

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Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y,
Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff
THM, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD (2008)
,
“Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis
in three populations”, Nat Genet 40:261–2

Nejentsev S, Walker N, Riches D, Egholm M, Todd JA (2009),
“Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect
Against Type 1 Diabetes”, Science 324 387–9:2009

Nejentsev S, Howson JMM, Walker NM, Szeszko JS, Field SF, Stevens
HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LMM, Smyth D, Bailey
R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA and The Wellcome Trust
Case Control Consortium (2007)
, “Localisation of type 1
diabetes susceptibility to the MHC class I genes HLA-B and HLA-A”, Nature
450:887–92

Royal Society Research Fellow
Dr Sergey  Nejentsev

Contact Details

Takes PhD students
Not available for consultancy

Affiliations

Classifications: 
Person keywords: 
Genomics
Autoimmunity
Genetics
Latency
Host-Pathogen Interaction
Innate Immunity
Infection
Host
Sequencing
Immune Evasion
Signalling
Gene Expression