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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge

Studying at Cambridge

 

Dr. Alex Borodavka

Dr. Alex Borodavka

Department of Biochemistry, Henry Dale Fellow

Interested in the molecular principles of multi-segmented genome packaging and RNA-controlled self-assembly in viruses.


Departments and Institutes

Biochemistry:

Research Interests

My long-term goal is to uncover the assembly and replication mechanisms of multi-segmented RNA viruses, including rotaviruses, with sufficient detail to identify novel anti-viral targets and improve existing vaccines.

To achieve this, I use a spectrum of techniques, ranging from single-molecule fluorescence, super-resolution imaging to high-throughput RNA structure probing tools. We use single-molecule assays for investigating inter-segment RNA-RNA interactions in rotaviruses and identifying the key RNA-binding proteins mediating these interactions. Our recent discoveries have raised a number of new questions about the mechanisms of multi-segmented virus genome assembly, which I will be pursuing as a new Research Fellow in Cambridge.

Key projects, countries, and partners:

Germany, Munich: LMU (Don Lamb) and MPI (Ralf Jungmann)
USA, Chapel Hill, UNC (Alain Laederach)
USA, Wake Forest University (Sarah McDonald)
Italy, Trieste, ICGEB (Oscar Burrone)

Keywords

  • Virion assembly
  • Immune Evasion
  • Molecular Biology
  • Host-Pathogen Interaction
  • Virology
  • Single-molecule fluorescence
  • Biophysics
  • Gene Regulation
  • Gene Expression
  • Genome Packaging

Topics

  • Rotavirus
  • RNA virus