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An Interdisciplinary Research Centre at the University of Cambridge


Professor of Medicine

Head of Department of Medicine


Combines genetics, genomics, immunology and clinical medicine, integrating detailed laboratory analysis of mechanisms of immune regulation with a prospective translational medicine programme in major autoimmune and inflammatory diseases. The main focus of the group is investigation of the biology underlying clinical outcome in immune-mediated disease.

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Key publications: 

Lee JC , … Smith KG; Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell 2013. DOI: 10.1016/j.cell.2013.08.034.

McKinney EF … Smith KG; T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection. Nature 2015. DOI: 10.1038/nature14468.

Lee JC … Smith KG. Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn’s disease. Nature Genetics 2017. DOI: 10.1038/ng.3755.

Lee JC … Smith KGC; A blood-based prognostic biomarker in inflammatory bowel disease. Gut 2019. DOI: 10.1101/535153.

Espeli M … Smith KGC; FcgRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human. Nature Communications 2019 In Press.

Department of Medicine
Basic immunological mechanisms, and how defects in regulatory control of the immune system can lead to autoimmunity and alter defence against infection.
Professor Kenneth  Smith
Not available for consultancy


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