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Cambridge Infectious Diseases

An Interdisciplinary Research Centre at the University of Cambridge
 

Biography

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BSc (Hons) Biochemistry, University of Glasgow

DPhil Biochemistry
University of Sussex.  

SRC Postdoctoral Fellowship,
Dept Biochemistry, U. Sussex.

Postdoctoral Fellow, University of Illinois
at the Medical Center,
Chicago,USA.

ARC Postdoctoral Research Fellowship,
Immunology Department, Middlesex
Hospital Medical
School.

Honorary Lecturer, Dept
Biochemistry, St Mary's Hospital Medical  School.

Wellcome Trust Senior Research
Fellow
, Immunology Department, Middlesex
Hospital Medical
School.

Wellcome Trust Senior Lecturer,
Immunology Division, University College and Middlesex Schools
of Medicine.

Reader in Experimental Immunology University
College, London

Lecturer, Department of
Pathology, University
of Cambridge.

Reader in Immunology, Department
of Pathology, University
of Cambridge.

Professor of Immunobiology,
Department of Pathology, University
of Cambridge.

Honorary Fellow, University College,
London.

Fellow of the Academy of Medical
Sciences

Honorary
Degree
University of Copenhagen

 

Research

Autoimmune diseases such as Type 1 diabetes are increasing in incidence in the developed world faster than can be acounted for by genetic change. Onset of Type 1 diabetes and most other autoimmune diseases is governed by both genetic and environmental factors. Our study of environmental factors has highlighted a key role for infection in reducing the incidence of Type 1 diabetes. We find that protection from diabetes arises through an interaction between the infectious agent and the innate immune system such that circuits which regulate the autoimmune response are reinforced. These studies are carried out in collaboration with Professor D Dunne (Microbiology and Parasitology) and Dr P Mastroeni at the Vet School.

Many genes influence the development of Type 1 diabetes. While some genes such as those encoding MHC class II molecules play a major role other genes have been more difficult to identify. Dr Jenny Nichols and I have generated NOD ES cells and these will be used to identify and characterise genes involved in diabetes development in NOD mice.

Publications

Key publications: 

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Zaccone
P, Burton OT, Gibbs S, Miller N, Jones FM, Dunne DW, Cooke A.(2010) Immunomodulation
by Schistosoma mansoni antigens in NOD mice: effects on both innate and
adaptive immune systems.
J Biomed Biotechnol. 2010:795210; 1-11.

 Burton,
OT, Gibbs S, Miller N, Jones,FM,  Wen L,
Dunne D, Cooke, A and Paola Zaccone
(2010) Importance of
TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens.

Eur J Immunol 40:2221-9.

Lehuen A, Diana J, Zaccone P and Cooke A.
(2010) Immune cell crosstalk in Type 1 diabetes. Nature Reviews Immunology 10:501-13.

 Burton
OT, Zaccone P, Phillips JM, De La Peña H, Fehérvári Z, Azuma M, Gibbs S,
Stockinger B, Cooke A. (2010) Roles for TGF-beta and programmed
cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression
by zymosan in nonobese diabetic mice.
J Immunol. 185:2754-62.

 Bending
D, Newland S, Krejcí A, Phillips JM, Bray S, Cooke A. (2011) Epigenetic changes at Il12rb2 and
Tbx21 in relation to plasticity behavior of Th17 cells
. J Immunol.
186:3373-82

  Zaccone P
and Cooke A (2011) Infectious
triggers protect from autoimmunity.
Seminars in Immunol. 23:122-9.

 

 

Professor of Immunobiology
Professor Anne  Cooke

Contact Details

Department of Pathology
Tennis Court Rd
Cambridge
CB21QP
01223 333907
Not available for consultancy

Affiliations

Classifications: 
Person keywords: 
Autoimmunity
Immunology
Host-Pathogen Interaction
Innate Immunity
Infection
Inflammation
Dendritic Cells