We focus on the replication and transcription of the influenza A virus. This process is driven by the viral RNA polymerase. In addition to copying the viral genome, the RNA polymerase generates aberrant RNA molecules that can induce innate immune responses. To study how the viral RNA polymerase works at a molecular level, we use in vitro activity assays and single-molecule experiments.
Key Projects, Countries, and Partners
Current collaborators:
Prof Wendy Barclay - Imperial College, London, UK
Dr Debby van Riel - Erasmus University, Rotterdam, the Netherlands
Dr Emmie de Wit - NIH, Montana, United States
